PMID- 38517560
OWN - NLM
STAT- Publisher
LR  - 20240322
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
DP  - 2024 Mar 22
TI  - Efficacy and Safety of Anhydrous Ethanol-Assisted Endoscopic Ultrasound-Guided 
      Transluminal Necrosectomy in Infected Necrotizing Pancreatitis.
LID - 10.1007/s10620-024-08389-7 [doi]
AB  - AIM: Endoscopic necrosectomy has become the first-line treatment option for 
      infectious necrotizing pancreatitis (INP), especially walled-off necrosis. 
      However, the problems, including operation-related adverse events (AEs) and the 
      need for multiple endoscopic procedures, have not been effectively addressed. We 
      sought to evaluate the clinical safety and efficacy of anhydrous ethanol-assisted 
      endoscopic ultrasound (EUS)-guided transluminal necrosectomy in INP. METHODS: A 
      single-center observational cohort study of INP patients was conducted in a 
      tertiary endoscopic center. Anhydrous ethanol-assisted EUS-guided transluminal 
      necrosectomy (modified group) and conventional endoscopic necrosectomy 
      (conventional group) were retrospectively compared in INP patients. The technical 
      and clinical success rates, operation time, perioperative AEs, postoperative 
      hospital stay, and recurrent INP rates were analyzed, respectively. RESULTS: 
      A total of 55 patients were enrolled. No statistically significant differences 
      were observed between the two groups regarding baseline characteristics. Compared 
      to patients in the conventional group, patients in the modified group 
      demonstrated significantly reduced times of endoscopic transluminal 
      necrosectomies (1.96 +/- 0.89 vs. 2.73 +/- 0.98; P = 0.004) and comparable 
      perioperative AEs (P = 0.35). Meanwhile, no statistically significant differences 
      were observed in the technical and clinical success rates (P = 0.92), operation 
      time (P = 0.59), postoperative hospital stay (P = 0.36), and recurrent INP rates 
      (P = 1.00) between the two groups. CONCLUSION: Anhydrous ethanol-assisted 
      EUS-guided transluminal necrosectomy seemed safe and effective in treating INP. 
      Compared with conventional endoscopic transluminal necrosectomy, its advantage 
      was mainly in reducing the number of endoscopic necrosectomies without increasing 
      perioperative AEs.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Zeng, Yan
AU  - Zeng Y
AUID- ORCID: 0000-0003-4935-1306
AD  - Department of Psychology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400010, China.
FAU - Zhang, Jun-Wen
AU  - Zhang JW
AUID- ORCID: 0000-0003-2911-598X
AD  - Department of Gastroenterology, The First Affiliated Hospital of Chongqing 
      Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
FAU - Yang, Jian
AU  - Yang J
AUID- ORCID: 0000-0001-8170-0727
AD  - Department of Gastroenterology, The First Affiliated Hospital of Chongqing 
      Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China. 
      yangjian@hospital.cqmu.edu.cn.
LA  - eng
GR  - W0138/the Program for Youth Innovation in Future Medicine, Chongqing Medical 
      University, China/
GR  - CMER202305/Education and Teaching Reform Project of the First Clinical College of 
      Chongqing Medical University/
PT  - Journal Article
DEP - 20240322
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - IM
OTO - NOTNLM
OT  - Anhydrous ethanol
OT  - Efficacy
OT  - Endoscopic transluminal necrosectomy
OT  - Endoscopic ultrasound
OT  - Infected necrotizing pancreatitis
OT  - Safety
EDAT- 2024/03/22 18:44
MHDA- 2024/03/22 18:44
CRDT- 2024/03/22 12:20
PHST- 2024/01/21 00:00 [received]
PHST- 2024/03/11 00:00 [accepted]
PHST- 2024/03/22 18:44 [medline]
PHST- 2024/03/22 18:44 [pubmed]
PHST- 2024/03/22 12:20 [entrez]
AID - 10.1007/s10620-024-08389-7 [pii]
AID - 10.1007/s10620-024-08389-7 [doi]
PST - aheadofprint
SO  - Dig Dis Sci. 2024 Mar 22. doi: 10.1007/s10620-024-08389-7.