PMID- 38517943
OWN - NLM
STAT- Publisher
LR  - 20240322
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
DP  - 2024 Mar 22
TI  - Integrating metabolomics and network pharmacology to assess the effects of 
      Mahuang Xixin Fuzi decoction on migraine rats induced by nitroglycerin.
LID - rgae025 [pii]
LID - 10.1093/jpp/rgae025 [doi]
AB  - OBJECTIVES: This study was designed to investigate the pharmacological activity 
      and therapeutic mechanism of Mahuang Xixin Fuzi decoction (MXFD) on migraine. 
      METHODS: Migraine model rats induced by nitroglycerin were established, and then 
      orally administered with MXFD for 7 days. Blood and urine samples were collected 
      to identify differential metabolites with metabolomics. To integrate the findings 
      from network pharmacology and metabolomics analysis, the metabolites and targets 
      related to MXFD therapy for migraine were filtered. KEY FINDINGS: MXFD was found 
      to alleviate the symptoms of migraines in rats. After treatment with MXFD, nine 
      metabolites were found to be regulated and returned to normal levels. MXFD acted 
      directly on nine key targets including MAOB, MAOA, ADRB1, ADRB2, ADRB3, ADORA2A, 
      ADORA2B, DRD5, and HTR4 and regulated two out of nine metabolites, namely 
      deoxycholic acid and 5-methoxyindoleacetate. CONCLUSIONS: The study found that 
      MXFD can alleviate migraines through multitarget and multicomponent interaction 
      networks.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the Royal 
      Pharmaceutical Society.
FAU - Ge, Fei
AU  - Ge F
AUID- ORCID: 0000-0001-8458-1401
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
FAU - Zhang, Yao
AU  - Zhang Y
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
FAU - Luo, Yamin
AU  - Luo Y
AD  - Bejing Research Institute of Chinese Medicine, Beijing University of Chinese 
      Medicine, 100029 Beijing, China.
FAU - Wang, Chunguo
AU  - Wang C
AD  - Bejing Research Institute of Chinese Medicine, Beijing University of Chinese 
      Medicine, 100029 Beijing, China.
FAU - Lu, Yixing
AU  - Lu Y
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
FAU - Zhao, Yafang
AU  - Zhao Y
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
FAU - Zhang, Di
AU  - Zhang D
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
FAU - Meng, Fengxian
AU  - Meng F
AD  - Dongfang Hospital of Beijing University of Traditional Chinese Medicine, 100078 
      Beijing, China.
FAU - Zhang, Dongmei
AU  - Zhang D
AD  - Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, 
      Dongzhimen Hospital, 101121 Beijing, China.
FAU - Chen, Meng
AU  - Chen M
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
FAU - Tao, Xiaohua
AU  - Tao X
AD  - College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      100029 Beijing, China.
AD  - Research Institute of Chinese Medicine Literature, Beijing University of Chinese 
      Medicine, 100029 Beijing, China.
LA  - eng
GR  - 81974542/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20240322
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
SB  - IM
OTO - NOTNLM
OT  - Mahuang-Xixin-Fuzi decoction
OT  - metabolomics
OT  - migraine
OT  - network pharmacology
EDAT- 2024/03/22 18:44
MHDA- 2024/03/22 18:44
CRDT- 2024/03/22 13:53
PHST- 2023/10/23 00:00 [received]
PHST- 2024/02/24 00:00 [accepted]
PHST- 2024/03/22 18:44 [medline]
PHST- 2024/03/22 18:44 [pubmed]
PHST- 2024/03/22 13:53 [entrez]
AID - 7633714 [pii]
AID - 10.1093/jpp/rgae025 [doi]
PST - aheadofprint
SO  - J Pharm Pharmacol. 2024 Mar 22:rgae025. doi: 10.1093/jpp/rgae025.