PMID- 38517982
OWN - NLM
STAT- Publisher
LR  - 20240322
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
DP  - 2024 Mar 22
TI  - First in-human clinical performance of a novel non-cavitating hand-held 
      lensectomy system in 665 consecutive cataract surgeries.
LID - 10.1097/j.jcrs.0000000000001446 [doi]
AB  - PURPOSE: To investigate the intraoperative performance and lens fragmentation 
      efficacy of a non-cavitating handheld lensectomy system in mild, moderate, and 
      severe cataract. SETTING: Ambulatory surgical centers. DESIGN: Retrospective 
      consecutive case series. METHODS: 665 consecutive eyes underwent cataract surgery 
      by 12 surgeons using a novel handheld non-cavitating lensectomy system for 
      nuclear fragmentations and extraction. Intraoperative measurements included 
      surgical time, miLOOP pre-treatment, and irrigation fluid use. RESULTS: Of the 
      665 eyes, 38 (6%), 468 (70%), 126 (19%) and 33 (5%) were Grades 1, 2, 3 and 4 
      nuclear densities, respectively, as graded by the surgeon intraoperatively. 
      Successful nuclear fragmentation, lens extraction and cortical removal were 
      achieved in all eyes. Total nucleus fragmentation and extraction times were 70.1, 
      100.3, 132.6 and 287.9 seconds for grades 1,2,3 and 4 respectively (p < 0.001). 
      Additionally, irrigation and aspiration (I/A) cortical removal times were 64.1, 
      51.1, 48.5 and 59.0 seconds respectively (p = 0.14). There was a low rate of 
      capsular tear (3 cases in 665 surgeries, 0.45%) and no other emergent adverse 
      events (AEs). CONCLUSION: The miCOR handheld non-cavitating lensectomy system 
      demonstrated nuclear fragmentation and extraction in the absence of intraocular 
      cavitation across all grades of nuclear densities.
CI  - Copyright (c) 2024 Published by Wolters Kluwer on behalf of ASCRS and ESCRS.
FAU - Ianchulev, Sean
AU  - Ianchulev S
AD  - Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
FAU - Yeu, Elizabeth
AU  - Yeu E
AUID- ORCID: 0000-0002-3453-3062
AD  - Refractive Surgery, Virginia Eye Consultants, Norfolk, Virginia, USA.
FAU - Hu, Edward H
AU  - Hu EH
AD  - Wolfe Eye Clinic, Marshalltown, IA, USA.
FAU - Singh, Paul
AU  - Singh P
AD  - The Eye Centers of Racine and Kenosha, Racine, Wisconsin.
FAU - Kamthan, Gautam
AU  - Kamthan G
AUID- ORCID: 0000-0002-7904-3307
AD  - Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
FAU - Li, Gavin
AU  - Li G
AUID- ORCID: 0000-0002-4318-7966
AD  - Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
FAU - Pantanelli, Seth
AU  - Pantanelli S
AUID- ORCID: 0000-0003-4992-9606
AD  - Department of Ophthalmology, Penn State College of Medicine, Hershey, 
      Pennsylvania, USA.
FAU - Tyson, Farrell
AU  - Tyson F
AD  - The Cape Coral Eye Center (Tyson), Cape Coral, Florida, USA.
LA  - eng
PT  - Journal Article
DEP - 20240322
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
SB  - IM
EDAT- 2024/03/22 18:44
MHDA- 2024/03/22 18:44
CRDT- 2024/03/22 14:13
PHST- 2024/01/24 00:00 [received]
PHST- 2024/03/14 00:00 [accepted]
PHST- 2024/03/22 18:44 [medline]
PHST- 2024/03/22 18:44 [pubmed]
PHST- 2024/03/22 14:13 [entrez]
AID - 02158034-990000000-00396 [pii]
AID - 10.1097/j.jcrs.0000000000001446 [doi]
PST - aheadofprint
SO  - J Cataract Refract Surg. 2024 Mar 22. doi: 10.1097/j.jcrs.0000000000001446.