PMID- 38521900 OWN - NLM STAT- MEDLINE DCOM- 20240325 LR - 20240326 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 25 IP - 1 DP - 2024 Mar 23 TI - Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters. PG - 139 LID - 10.1186/s12931-024-02764-8 [doi] LID - 139 AB - BACKGROUND: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology. METHODS: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman's rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. RESULTS: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified. CONCLUSION: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies. CI - (c) 2024. The Author(s). FAU - Hsu, Yuan-Ting AU - Hsu YT AD - National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. AD - National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan. FAU - Wu, Chao-Chien AU - Wu CC AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Wang, Chin-Chou AU - Wang CC AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. AD - Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Sheu, Chau-Chyun AU - Sheu CC AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Yang, Yi-Hsin AU - Yang YH AD - National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. FAU - Cheng, Ming-Yen AU - Cheng MY AD - Department of Mathematics, Hong Kong Baptist University, Hong Kong, China. FAU - Lai, Ruay-Sheng AU - Lai RS AD - Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. FAU - Leung, Sum-Yee AU - Leung SY AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Lin, Chi-Cheng AU - Lin CC AD - Chest Division, Department of Internal Medicine, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Ping-Tung, Taiwan. FAU - Wei, Yu-Feng AU - Wei YF AD - Department of Internal Medicine, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan. FAU - Lai, Yung-Fa AU - Lai YF AD - Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. FAU - Cheng, Meng-Hsuan AU - Cheng MH AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Chen, Huang-Chi AU - Chen HC AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Yang, Chih-Jen AU - Yang CJ AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Wang, Chien-Jen AU - Wang CJ AD - National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. FAU - Liu, Huei-Ju AU - Liu HJ AD - National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. FAU - Chen, Hua-Ling AU - Chen HL AD - National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. FAU - Hung, Chih-Hsing AU - Hung CH AD - Department of Pediatrics, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. pedhung@gmail.com. AD - Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. pedhung@gmail.com. AD - Department of Pediatrics, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. pedhung@gmail.com. FAU - Lee, Chon-Lin AU - Lee CL AD - Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan. a0780047@g-mail.nsysu.edu.tw. AD - Department of Marine Environment and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan. a0780047@g-mail.nsysu.edu.tw. FAU - Huang, Ming-Shyan AU - Huang MS AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. ed110209@edah.org.tw. AD - Division of Chest Medicine, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. ed110209@edah.org.tw. FAU - Huang, Shau-Ku AU - Huang SK AD - National Institute of Environmental Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. skhuang@nhri.edu.tw. AD - Johns Hopkins University School of Medicine, Baltimore, MD, USA. skhuang@nhri.edu.tw. LA - eng GR - CDA 10-014/HX/HSRD VA/United States PT - Journal Article DEP - 20240323 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - 6O7F7IX66E (phthalic acid) RN - FU2EWB60RT (mono-(2-ethylhexyl)phthalate) RN - C42K0PH13C (Diethylhexyl Phthalate) RN - 0 (Cytokines) RN - 0 (Phthalic Acids) SB - IM MH - Adult MH - Animals MH - Humans MH - *Diethylhexyl Phthalate/toxicity/urine/*analogs & derivatives MH - Environmental Exposure MH - *Diabetes Mellitus, Type 2 MH - Case-Control Studies MH - *Asthma/chemically induced/diagnosis/epidemiology MH - Cytokines MH - *Hypertension MH - *Phthalic Acids PMC - PMC10960985 OTO - NOTNLM OT - Asthma phenotype OT - Comorbidities OT - DEHP OT - HEL OT - Inflammatory markers COIS- The authors declare no competing interests. EDAT- 2024/03/24 06:42 MHDA- 2024/03/25 06:43 PMCR- 2024/03/23 CRDT- 2024/03/24 00:26 PHST- 2023/10/16 00:00 [received] PHST- 2024/03/10 00:00 [accepted] PHST- 2024/03/25 06:43 [medline] PHST- 2024/03/24 06:42 [pubmed] PHST- 2024/03/24 00:26 [entrez] PHST- 2024/03/23 00:00 [pmc-release] AID - 10.1186/s12931-024-02764-8 [pii] AID - 2764 [pii] AID - 10.1186/s12931-024-02764-8 [doi] PST - epublish SO - Respir Res. 2024 Mar 23;25(1):139. doi: 10.1186/s12931-024-02764-8.