PMID- 38521949 OWN - NLM STAT- MEDLINE DCOM- 20240325 LR - 20240326 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 25 IP - 1 DP - 2024 Mar 23 TI - Editorial for special issue-human precision cut lung slices: an Ex vivo platform for therapeutic target discovery and drug testing in lung disease. PG - 137 LID - 10.1186/s12931-024-02756-8 [doi] LID - 137 AB - Publications utilizing precision cut lung slices (PCLS) steadily increased from the 1970's, with a significant increase in 2010, to tripling by 2023. PCLS have been used to study a vast array of pulmonary diseases and exposures to pathogens and toxicants to understand pathogenesis of disease but also to examine basic cellular mechanisms that underly lung biology. This Special Issue will highlight new, exciting, and novel research using PCLS, while acknowledging the substantial fund of knowledge that has been gained using this platform. CI - (c) 2024. The Author(s). FAU - Koziol-White, Cynthia J AU - Koziol-White CJ AD - Rutgers Institute for Translational Medicine and Science, Rutgers University, 89 French Street, Room 4268, New Brunswick, NJ, 08901, USA. cjk167@rbhs.rutgers.edu. FAU - Panettieri, Reynold A Jr AU - Panettieri RA Jr AD - Rutgers Institute for Translational Medicine and Science, Rutgers University, 89 French Street, Room 4268, New Brunswick, NJ, 08901, USA. LA - eng GR - P01 HL114471/HL/NHLBI NIH HHS/United States PT - Letter DEP - 20240323 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 SB - IM MH - Humans MH - *Lung/pathology MH - *Lung Diseases/diagnosis/drug therapy/pathology MH - Organ Culture Techniques PMC - PMC10960987 OTO - NOTNLM OT - Airway physiology in precision cut lung slices OT - Precision cut lung slices OT - Respiratory therapeutics COIS- The authors declare no competing interests. EDAT- 2024/03/24 06:42 MHDA- 2024/03/25 06:42 PMCR- 2024/03/23 CRDT- 2024/03/24 00:29 PHST- 2024/02/20 00:00 [received] PHST- 2024/03/04 00:00 [accepted] PHST- 2024/03/25 06:42 [medline] PHST- 2024/03/24 06:42 [pubmed] PHST- 2024/03/24 00:29 [entrez] PHST- 2024/03/23 00:00 [pmc-release] AID - 10.1186/s12931-024-02756-8 [pii] AID - 2756 [pii] AID - 10.1186/s12931-024-02756-8 [doi] PST - epublish SO - Respir Res. 2024 Mar 23;25(1):137. doi: 10.1186/s12931-024-02756-8.