PMID- 38522142
OWN - NLM
STAT- MEDLINE
DCOM- 20240410
LR  - 20240410
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 131
DP  - 2024 Apr 20
TI  - A cluster of type I interferon-regulated genes associates with disease activity 
      and prognosis in patients with IgA nephropathy.
PG  - 111920
LID - S1567-5769(24)00438-7 [pii]
LID - 10.1016/j.intimp.2024.111920 [doi]
AB  - The exact pathogenesis of IgA nephropathy (IgAN) is complex and so far, not well 
      defined. Since it has been shown that microbial infections could induce high 
      levels of type I interferon (IFN-I) and there is an evident link between mucosal 
      infection and gross hematuria in IgAN, we hypothesized that IFN-I may play a role 
      in the pathogenic process. In this study, we investigated the type I interferon 
      status in IgAN based on the expression of 17 IFN-regulated genes (IRGs) in whole 
      blood from 59 IgAN patients in a cross-sectional study, of which 34 patients 
      followed longitudinally. Analysis of the IFN-score showed that there was a 
      significant elevated IFN-score in the IgAN patients compared with healthy 
      controls (n = 28, p = 9.80 x 10(-3)), and we observed an elevated IFN-score in 
      the group with less tubular atrophy/interstitial fibrosis (p = 1.07 x 10(-2)) and 
      with a lower proportion of mesangial hypercellularity (p = 1.23 x 10(-2)). In the 
      longitudinal analysis, Cox regression analysis revealed that a higher IFN level 
      was associated with a better renal outcome in IgAN after adjustments for gender 
      and age (hazard ratio, 0.90; 95 % confidence interval, 0.81 to 0.97; 
      p = 4.20 x 10(-2)). In conclusion, our finding suggested that IFN score may 
      represent a novel type of biomarker in IgAN, which requires further exploration 
      on its mechanism and therapeutic targeting.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Qu, Shu
AU  - Qu S
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Gan, Ting
AU  - Gan T
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Wang, Yan-Na
AU  - Wang YN
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Qi, Yuan-Yuan
AU  - Qi YY
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Zhang, Yue-Miao
AU  - Zhang YM
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Berthier, Celine C
AU  - Berthier CC
AD  - Division of Nephrology, Department of Internal Medicine, University of Michigan, 
      Ann Arbor, MI, USA.
FAU - Liu, Li-Jun
AU  - Liu LJ
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Shi, Su-Fang
AU  - Shi SF
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Lv, Ji-Cheng
AU  - Lv JC
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China.
FAU - Zhou, Xu-Jie
AU  - Zhou XJ
AD  - Renal Division, Peking University First Hospital, Beijing, China; Key Laboratory 
      of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of 
      Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of 
      Education, Beijing, China; Research Units of Diagnosis and Treatment of 
      Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 
      China. Electronic address: zhouxujie@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240323
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Humans
MH  - *Glomerulonephritis, IGA/genetics/drug therapy
MH  - *Interferon Type I/genetics/therapeutic use
MH  - Cross-Sectional Studies
MH  - Prognosis
MH  - Kidney/pathology
OTO - NOTNLM
OT  - Immunoglobulin A nephropathy
OT  - Interferon signature
OT  - Interferon-regulated genes
OT  - Oxford Classification
OT  - Prognosis
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/25 00:42
MHDA- 2024/04/10 06:43
CRDT- 2024/03/24 19:01
PHST- 2023/11/28 00:00 [received]
PHST- 2024/03/17 00:00 [revised]
PHST- 2024/03/20 00:00 [accepted]
PHST- 2024/04/10 06:43 [medline]
PHST- 2024/03/25 00:42 [pubmed]
PHST- 2024/03/24 19:01 [entrez]
AID - S1567-5769(24)00438-7 [pii]
AID - 10.1016/j.intimp.2024.111920 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2024 Apr 20;131:111920. doi: 10.1016/j.intimp.2024.111920. 
      Epub 2024 Mar 23.