PMID- 38522418
OWN - NLM
STAT- Publisher
LR  - 20240324
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
DP  - 2024 Mar 22
TI  - Immunoglobulin E-Mediated Food Sensitization in a Moroccan Pediatric Population 
      with Celiac Disease.
PG  - 1-10
LID - 10.1159/000536282 [doi]
AB  - INTRODUCTION: Celiac disease is a chronic autoimmune disorder that occurs 
      following the ingestion of gluten, in genetically predisposed individuals. 
      Patients with celiac disease, especially children, are likely prone to develop 
      allergic reactions to different food allergens. However, the relationship between 
      food allergy and celiac disease remains not elucidated. The aim of this 
      pioneering study was to evaluate the prevalence of allergic food sensitization in 
      children with celiac disease in Morocco. METHODS: A total of 57 children with 
      confirmed celiac disease, including 25 males and 32 females with a mean age of 
      8.6 +/- 4.4 years, underwent a food allergen-specific immunoglobulin E (IgE) 
      screening. This screening was conducted using a multiparametric immunodot assay 
      (Euroline Food "Maghreb," Euroimmun). Statistical analysis was performed using R 
      software. RESULTS: Among the 57 cases tested, the overall rate of IgE-mediated 
      sensitization to food allergens was found to be 48% (27/57), dominated by 
      chicken, with 51.9% (14/27), followed by almond, 40.7% (11/27), sesame, 40.7% 
      (11/27), potato 33.3% (9/27), and apple 18.5% (5/27). Of the s-IgE positive 
      cases, 74% were sensitized at least to one allergen, 37% (10/27) were sensitized 
      to both chicken and almond allergens. A significant correlation was observed 
      between almond, sesame, chicken, and potato. CONCLUSION: The current study 
      highlighted a high prevalence of food allergen sensitization in children with 
      celiac disease. This underlines the potential benefit in screening for food 
      allergy in celiac patients.
CI  - (c) 2024 S. Karger AG, Basel.
FAU - Ait Said, Hasna
AU  - Ait Said H
AD  - Molecular Engineering, Biotechnology and Innovation Team, Geo-Bio-Environment 
      Engineering and Innovation Laboratory, Polydisciplinary Faculty of Taroudannt, 
      IBN ZOHR University, Taroudannt, Morocco.
AD  - Biotechnology, Environment and Health Team, Laboratory of Sciences of Health and 
      Environment, High Institute of Nursing Professions and Health Techniques, ISPITS 
      Agadir-Annex Tiznit, Tiznit, Morocco.
FAU - Elmoumou, Lahcen
AU  - Elmoumou L
AD  - Molecular Engineering, Biotechnology and Innovation Team, Geo-Bio-Environment 
      Engineering and Innovation Laboratory, Polydisciplinary Faculty of Taroudannt, 
      IBN ZOHR University, Taroudannt, Morocco.
AD  - Biotechnology, Environment and Health Team, Laboratory of Sciences of Health and 
      Environment, High Institute of Nursing Professions and Health Techniques, ISPITS 
      Agadir-Annex Tiznit, Tiznit, Morocco.
FAU - Guennouni, Morad
AU  - Guennouni M
AD  - Chouaib Doukkali University of El Jadida, Higher School of Education and 
      Training, Science and Technology Team, El Jadida, Morocco.
FAU - Rherissi, Bouchra
AU  - Rherissi B
AD  - Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences, IBN ZOHR 
      University, Agadir, Morocco.
FAU - Oujamaa, Ider
AU  - Oujamaa I
AD  - Laboratory of Immunology and Centre of Clinical Research, Mohamed VI University 
      Hospital, Marrakech, Morocco.
FAU - Eddehbi, Fatima-Ezzahra
AU  - Eddehbi FE
AD  - Laboratory of Immunology and Centre of Clinical Research, Mohamed VI University 
      Hospital, Marrakech, Morocco.
FAU - Lamjadli, Saad
AU  - Lamjadli S
AD  - Laboratory of Immunology and Centre of Clinical Research, Mohamed VI University 
      Hospital, Marrakech, Morocco.
FAU - Hazime, Raja
AU  - Hazime R
AD  - Laboratory of Immunology and Centre of Clinical Research, Mohamed VI University 
      Hospital, Marrakech, Morocco.
FAU - Bourrahouat, Aicha
AU  - Bourrahouat A
AD  - Department of Pediatrics, Mohamed VI University Hospital, Marrakech, Morocco.
FAU - Ait Sab, Imane
AU  - Ait Sab I
AD  - Department of Pediatrics, Mohamed VI University Hospital, Marrakech, Morocco.
FAU - Admou, Brahim
AU  - Admou B
AD  - Laboratory of Immunology and Centre of Clinical Research, Mohamed VI University 
      Hospital, Marrakech, Morocco.
AD  - Biosciences Research Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad 
      University, Marrakech, Morocco.
FAU - El Kadmiri, Nadia
AU  - El Kadmiri N
AD  - Molecular Engineering, Biotechnology and Innovation Team, Geo-Bio-Environment 
      Engineering and Innovation Laboratory, Polydisciplinary Faculty of Taroudannt, 
      IBN ZOHR University, Taroudannt, Morocco.
LA  - eng
PT  - Journal Article
DEP - 20240322
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
SB  - IM
OTO - NOTNLM
OT  - Celiac disease
OT  - Children
OT  - Food allergy
OT  - Specific immunoglobulin E
EDAT- 2024/03/25 00:42
MHDA- 2024/03/25 00:42
CRDT- 2024/03/24 19:24
PHST- 2023/09/21 00:00 [received]
PHST- 2024/01/09 00:00 [accepted]
PHST- 2024/03/25 00:42 [medline]
PHST- 2024/03/25 00:42 [pubmed]
PHST- 2024/03/24 19:24 [entrez]
AID - 000536282 [pii]
AID - 10.1159/000536282 [doi]
PST - aheadofprint
SO  - Int Arch Allergy Immunol. 2024 Mar 22:1-10. doi: 10.1159/000536282.