PMID- 38523868
OWN - NLM
STAT- MEDLINE
DCOM- 20240326
LR  - 20240326
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with 
      and without macular edema: single-center cross-sectional analysis.
PG  - 1275200
LID - 10.3389/fendo.2023.1275200 [doi]
LID - 1275200
AB  - AIM: The retinal and choroidal parameters were analyzed to understand the 
      impairment of microcirculation of both retina and choroid in patients with 
      diabetic retinopathy (DR). METHODS: Fifty-five treatment-naive non-proliferative 
      diabetic retinopathy (NPDR) patients (75 eyes) with type 2 diabetes mellitus 
      (T2DM), including 28 patients (36 eyes) with diabetic macular edema (DME) and 27 
      patients (39 eyes) without DME, and 25 healthy subjects (47 eyes) were enrolled 
      in this study. The following parameters of DR patients with and without DME were 
      evaluated: the foveal avascular zone area (FAZ-a), FAZ perimeter (FAZ-p), FAZ 
      circularity index (FAZ-CI), total subfoveal choroidal area (TCA), luminal area 
      (LA), stromal area (SA), choroidal vascularity index (CVI), choriocapillaris flow 
      area percentage, superficial capillary plexus (SCP), and deep capillary plexus 
      (DCP). RESULTS: SCP, DCP, and the percentage of choriocapillaris flow area were 
      significantly different between DR patients with and without DME. The DR patients 
      presented lower LA, CVI, and FAZ-CI compared to those of healthy controls (all p 
      < 0.05). The percentage of choriocapillaris flow area in DR patients with and 
      without DME was significantly lower than that in healthy controls (p < 0.05). SCP 
      and DCP were significantly correlated with FAZ-a and FAZ-p but presented 
      insignificant associations with FAZ-CI. CONCLUSIONS: Optical coherence tomography 
      (OCT) and OCT angiography (OCTA) parameters, such as LA, CVI, FAZ-CI, and the 
      percentage of choriocapillaris flow area, were reduced compared to those in 
      controls, indicating that the microcirculations of the retina and choroid in the 
      macular area were impaired in DR patients with DME and without DME.
CI  - Copyright (c) 2024 Cui, Feng, Wu, Wang, Cui, Wang, Chang, Shang, Zhao, Liu and Qin.
FAU - Cui, Yanyan
AU  - Cui Y
AD  - Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, 
      China.
FAU - Feng, Dongfan
AU  - Feng D
AD  - Liaocheng People's Hospital, Liaocheng, China.
FAU - Wu, Changlong
AU  - Wu C
AD  - Jinan 2nd People's Hospital, Jinan, China.
FAU - Wang, Ping
AU  - Wang P
AD  - Ophthalmological Center, Affiliated Hospital of Weifang Medical University, 
      Weifang, China.
FAU - Cui, Ruoxi
AU  - Cui R
AD  - Nanchang University Queen Mary School, Nanchang, China.
FAU - Wang, Xiaokun
AU  - Wang X
AD  - Civil Aviation Medical Center of CAAC Northeast Regional Administration, 
      Shenyang, China.
FAU - Chang, Weiwei
AU  - Chang W
AD  - Department of Ophthalmology, Affiliated Hospital of Jining Medical University, 
      Jining, China.
FAU - Shang, Weiwei
AU  - Shang W
AD  - Liaocheng People's Hospital, Liaocheng, China.
FAU - Zhao, Bojun
AU  - Zhao B
AD  - Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Biostatistics, School of Public Health, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Qin, Xuejiao
AU  - Qin X
AD  - Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240308
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/complications
MH  - *Macular Edema/etiology/complications
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Tomography, Optical Coherence/methods
PMC - PMC10960358
OTO - NOTNLM
OT  - OCT
OT  - OCTA
OT  - choroidal vascularity index
OT  - diabetic macular edema
OT  - fovea avascular zone
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/25 06:43
MHDA- 2024/03/26 06:44
PMCR- 2023/01/01
CRDT- 2024/03/25 04:20
PHST- 2023/08/09 00:00 [received]
PHST- 2023/12/08 00:00 [accepted]
PHST- 2024/03/26 06:44 [medline]
PHST- 2024/03/25 06:43 [pubmed]
PHST- 2024/03/25 04:20 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1275200 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2024 Mar 8;14:1275200. doi: 
      10.3389/fendo.2023.1275200. eCollection 2023.