PMID- 38525134
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 1976-8257 (Print)
IS  - 2234-2753 (Electronic)
IS  - 1976-8257 (Linking)
VI  - 40
IP  - 2
DP  - 2024 Apr
TI  - Protective effect of cilostazol on vascular injury in rats with acute ischemic 
      stroke complicated with chronic renal failure.
PG  - 189-202
LID - 10.1007/s43188-023-00217-w [doi]
AB  - Chronic renal failure (CRF) resulting in vascular calcification, which does 
      damage to blood vessels and endothelium, is an independent risk factor for 
      stroke. It has been reported that cilostazol has a protective effect on the focal 
      cerebral ischemic infarct. However, its impact on vascular injury in CRF combined 
      stroke and its molecular protection mechanism have not been investigated. In this 
      study, we carried out the effect of cilostazol on CRF combined stroke rats, and 
      the results confirmed that it improved the neurobehavior, renal function as well 
      as pathologic changes in both the kidney and brain. In addition, the inflammation 
      and oxidative stress factors in the kidney and brain were suppressed. Moreover, 
      the rates of brain edema and infarction were decreased. The injured brain-blood 
      barrier (BBB) was recovered with less Evans blue extravasation and more 
      expressions of zonula occludens-1(ZO-1) and occludin. More cerebral blood flow 
      (CBF) in the ipsilateral hemisphere and more expression of CD31 and vascular 
      endothelial growth factor (VEGF) in brain and kidney were found in the cilostazol 
      group. Furthermore, cell apoptosis and cell autophagy became less, on the 
      contrary, proteins of vascular endothelial growth factor receptor 2 (VEGFR2) 
      after the cilostazol treatment were increased. More importantly, this protective 
      effect is related to the pathway of Janus Kinase (JAK)/signal transducer and 
      activator of transcription 3 (STAT3), mammalian target of rapamycin (mTOR), and 
      the hypoxia inducible factor-1alpha (HIF-1alpha). In conclusion, our results confirmed 
      that cilostazol exerted a protective effect on the brain and kidney function, 
      specifically in vascular injury, oxidative stress, cell apoptosis, cell 
      autophagy, and inflammation response in CRF combined with stroke rats which were 
      related to the upregulation of JAK/STAT3/mTOR signal pathway. SUPPLEMENTARY 
      INFORMATION: The online version contains supplementary material available at 
      10.1007/s43188-023-00217-w.
CI  - (c) The Author(s) 2023.
FAU - Sun, Ru
AU  - Sun R
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
FAU - Gu, Qun
AU  - Gu Q
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
FAU - Zhang, Xufeng
AU  - Zhang X
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
FAU - Zeng, Ruiqi
AU  - Zeng R
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
FAU - Chen, Dan
AU  - Chen D
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
FAU - Yao, Jingjing
AU  - Yao J
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
FAU - Min, Jingjing
AU  - Min J
AUID- ORCID: 0000-0002-0635-6492
AD  - Department of Neurology, the First People's Hospital of Huzhou, First affiliated 
      Hospital of Huzhou University, Huzhou, China. GRID: grid.411440.4. ISNI: 0000 
      0001 0238 8414
LA  - eng
PT  - Journal Article
DEP - 20231213
PL  - Singapore
TA  - Toxicol Res
JT  - Toxicological research
JID - 101483324
PMC - PMC10959867
OTO - NOTNLM
OT  - Chronic renal failure (CRF)
OT  - Cilostazol
OT  - Stroke
OT  - Vascular injury
COIS- Conflict of interestThe authors have no relevant financial or non-financial 
      interests to disclose.
EDAT- 2024/03/25 06:42
MHDA- 2024/03/25 06:43
PMCR- 2023/12/13
CRDT- 2024/03/25 04:37
PHST- 2023/03/10 00:00 [received]
PHST- 2023/10/16 00:00 [revised]
PHST- 2023/11/05 00:00 [accepted]
PHST- 2024/03/25 06:43 [medline]
PHST- 2024/03/25 06:42 [pubmed]
PHST- 2024/03/25 04:37 [entrez]
PHST- 2023/12/13 00:00 [pmc-release]
AID - 217 [pii]
AID - 10.1007/s43188-023-00217-w [doi]
PST - epublish
SO  - Toxicol Res. 2023 Dec 13;40(2):189-202. doi: 10.1007/s43188-023-00217-w. 
      eCollection 2024 Apr.