PMID- 38525744
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 2308-3417 (Electronic)
IS  - 2308-3417 (Linking)
VI  - 9
IP  - 2
DP  - 2024 Feb 26
TI  - Tirzepatide and Glycemic Control Metrics Using Continuous Glucose Monitoring in 
      Older Patients with Type 2 Diabetes Mellitus: An Observational Pilot Study.
LID - 10.3390/geriatrics9020027 [doi]
LID - 27
AB  - This observational pilot study aimed to investigate continuous glucose monitoring 
      (CGM) metrics in older Japanese patients with type 2 diabetes mellitus (T2DM) 
      using a CGM system (FreeStyle Libre Pro) during the first tirzepatide 
      administration and compare the glycemic control measures before and after the 
      initial injection. The four patients had a mean age of 79.5 years (standard 
      deviation [SD]: 5.8), a mean body mass index of 24.6 kg/m(2) (SD: 4.7), a mean 
      glycated hemoglobin level of 9.1% (SD: 2.1), and a mean measurement period of 
      10.5 days (SD: 3.5). After the inclusion of tirzepatide treatment, the mean of 
      time in range, time above range, and time below range changed from 53.2% to 78.9% 
      (p = 0.041), 45.8% to 19.7% (p = 0.038), and 1.0% to 1.5% (p = 0.206), 
      respectively. Improved hyperglycemia reduced the oral hypoglycemic medication in 
      two cases and decreased the frequency of insulin injections in two cases. To 
      elucidate the potential benefits of tirzepatide, future studies should 
      investigate the long-term impact on functional prognosis, safety, and 
      tolerability and distinguish between the use of other weekly agonists, especially 
      in nonobese older Asian patients. However, tirzepatide-associated robust glycemic 
      improvement may simplify diabetes treatment regimens in older patients with T2DM.
FAU - Omura, Takuya
AU  - Omura T
AUID- ORCID: 0000-0001-5490-8653
AD  - Department of Endocrinology and Metabolism, Hospital, National Center for 
      Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
AD  - Department of Metabolic Research, Research Institute, National Center for 
      Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
FAU - Inami, Akemi
AU  - Inami A
AD  - Department of Metabolic Research, Research Institute, National Center for 
      Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
FAU - Sugimoto, Taiki
AU  - Sugimoto T
AUID- ORCID: 0000-0002-6418-0755
AD  - Department of Prevention and Care Science, Research Institute, National Center 
      for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
AD  - Department of Medicine, University of Washington, Box 359780, 325 Ninth Avenue, 
      Seattle, WA 98104, USA.
FAU - Kawashima, Shuji
AU  - Kawashima S
AD  - Department of Endocrinology and Metabolism, Hospital, National Center for 
      Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
FAU - Sakurai, Takashi
AU  - Sakurai T
AD  - Department of Prevention and Care Science, Research Institute, National Center 
      for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
FAU - Tokuda, Haruhiko
AU  - Tokuda H
AD  - Department of Endocrinology and Metabolism, Hospital, National Center for 
      Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
AD  - Department of Metabolic Research, Research Institute, National Center for 
      Geriatrics and Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
AD  - Department of Clinical Laboratory, Hospital, National Center for Geriatrics and 
      Gerontology, 7-430 Morioka-cho, Obu 474-8511, Aichi, Japan.
LA  - eng
GR  - JP23K16812/Japan Society for the Promotion of Science/
GR  - 2023.3.7.9/Chukyo longevity medical research and promotion foundation/
GR  - 21-1/National Center for Geriatrics and Gerontology/
PT  - Case Reports
DEP - 20240226
PL  - Switzerland
TA  - Geriatrics (Basel)
JT  - Geriatrics (Basel, Switzerland)
JID - 101704019
PMC - PMC10961786
OTO - NOTNLM
OT  - continuous glucose monitoring
OT  - elderly
OT  - time in range
OT  - tirzepatide
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/25 06:43
MHDA- 2024/03/25 06:44
PMCR- 2024/02/26
CRDT- 2024/03/25 05:43
PHST- 2023/12/23 00:00 [received]
PHST- 2024/02/22 00:00 [revised]
PHST- 2024/02/24 00:00 [accepted]
PHST- 2024/03/25 06:44 [medline]
PHST- 2024/03/25 06:43 [pubmed]
PHST- 2024/03/25 05:43 [entrez]
PHST- 2024/02/26 00:00 [pmc-release]
AID - geriatrics9020027 [pii]
AID - geriatrics-09-00027 [pii]
AID - 10.3390/geriatrics9020027 [doi]
PST - epublish
SO  - Geriatrics (Basel). 2024 Feb 26;9(2):27. doi: 10.3390/geriatrics9020027.