PMID- 38526450
OWN - NLM
STAT- MEDLINE
DCOM- 20240409
LR  - 20240409
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 10
IP  - 4
DP  - 2024 Apr 8
TI  - A Supramolecular Assembly of EGCG for Long-Term Treatment of Allergic Rhinitis.
PG  - 2282-2298
LID - 10.1021/acsbiomaterials.4c00091 [doi]
AB  - Allergic rhinitis (AR) is a type-I hypersensitivity disease mediated by 
      immunoglobulin E (IgE). Although antihistamines, glucocorticoids, leukotriene 
      receptor antagonists, and other drugs are widely used to treat AR, the various 
      adverse side effects of long-term use of these drugs should not be ignored. 
      Therefore, more effective and safe natural alternative strategies are urgently 
      needed. To this end, this study designed a nanosupramolecular delivery system 
      composed of beta-cyclodextrin supramolecular polymer (PCD), thiolated chitosan 
      (TCS), and natural polyphenol epigallocatechin gallate (EGCG) for intranasal 
      topical continuous treatment of AR. The TCS/PCD@EGCG nanocarriers exhibited an 
      excellent performance in terms of retention and permeability in the nasal mucosa 
      and released the vast majority of EGCG responsively in the nasal 
      microenvironment, thus resulting in the significantly high antibacterial and 
      antioxidant capacities. According to the in vitro model, compared with free EGCG, 
      TCS/PCD@EGCG inhibited mast cell activity and abnormal histamine secretion in a 
      more long-term and sustained manner. According to the in vivo model, whether in 
      the presence of continuous or intermittent administration, TCS/PCD@EGCG 
      substantially inhibited the secretion of allergenic factors and inflammatory 
      factors, mitigated the pathological changes of nasal mucosa, alleviated the 
      symptoms of rhinitis in mice, and produced a satisfactory therapeutic effect on 
      AR. In particular, the therapeutic effect of TCS/PCD@EGCG systems were even 
      superior to that of budesonide during intermittent treatment. Therefore, the 
      TCS/PCD@EGCG nanocarrier is a potential long-lasting antiallergic medicine for 
      the treatment of AR.
FAU - Zhang, Fu Zhong
AU  - Zhang FZ
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Tan, Min
AU  - Tan M
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Zeng, Jing
AU  - Zeng J
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Qi, Xu-Wei
AU  - Qi XW
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Zhang, Ye-Tao
AU  - Zhang YT
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Che, Yu-Ting
AU  - Che YT
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Zhang, Sheng
AU  - Zhang S
AUID- ORCID: 0000-0003-0462-6724
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      of Sichuan University, Sichuan University, Chengdu 610065, China.
FAU - Li, Bang-Jing
AU  - Li BJ
AUID- ORCID: 0000-0002-0405-6883
AD  - Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, 
      Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
LA  - eng
PT  - Journal Article
DEP - 20240325
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8R1V1STN48 (Catechin)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Rhinitis, Allergic/drug therapy
MH  - Allergens/therapeutic use
MH  - Administration, Intranasal
MH  - Immunoglobulin E/therapeutic use
MH  - Catechin/*analogs & derivatives
OTO - NOTNLM
OT  - allergic rhinitis
OT  - epigallocatechin-3-gallate (EGCG)
OT  - long-lasting anti-inflammatory
OT  - polycyclodextrin
OT  - thiolated chitosan
EDAT- 2024/03/25 12:46
MHDA- 2024/04/09 06:45
CRDT- 2024/03/25 11:23
PHST- 2024/04/09 06:45 [medline]
PHST- 2024/03/25 12:46 [pubmed]
PHST- 2024/03/25 11:23 [entrez]
AID - 10.1021/acsbiomaterials.4c00091 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2024 Apr 8;10(4):2282-2298. doi: 
      10.1021/acsbiomaterials.4c00091. Epub 2024 Mar 25.