PMID- 38529400
OWN - NLM
STAT- MEDLINE
DCOM- 20240327
LR  - 20240327
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 15
DP  - 2024
TI  - Causal relationship between genetically predicted type 2 diabetes mellitus and 
      male infertility.
PG  - 1357279
LID - 10.3389/fendo.2024.1357279 [doi]
LID - 1357279
AB  - BACKGROUND: Diabetes mellitus (DM) stands as the most prevalent endocrine 
      abnormality affecting the physiological systems and organs and impairing the male 
      reproductive functions. Type 2 Diabetes Mellitus (T2DM), accounting for about 
      90-95% of DM, is closely associated with male infertility. However, the magnitude 
      of the causal relationships between T2DM and male infertility remains unclear. 
      The current investigation was to explore the causal relationship between T2DM and 
      male infertility utilizing the Mendelian Randomization (MR) analysis. METHODS: A 
      two-sample MR (2SMR) analysis was conducted to investigate the causal 
      relationship between T2DM and male infertility in the European population from 
      the genome-wide association study (GWAS) summary data that was publicly 
      accessible. GWAS for T2DM and male infertility were extracted from the IEU Open 
      GWAS Project database, with the resulting data encompassing 680 cases and 72,799 
      controls as the outcome data. Five MR methods were employed for the 2SMR 
      analyses, namely the MR-Egger, weighted median estimation (WME), weighted mode 
      (WM), inverse-variance weighted (IVW), and simple mode. The primary analytical 
      technique utilized in this study was the IVW method, and a multivariate MR 
      analysis was executed to examine the potential mediating influences of T2DM on 
      male infertility. RESULTS: Following were the odds ratios (ORs) and associated 
      95% CIs derived from IVW (fixed effects), MR-Egger, WM, WME, and simple mode 
      approaches: 0.824 (95% CI 0.703-0.966), 0.726 (95% CI 0.527-1.001), 0.827 (95% CI 
      0.596-1.150), 0.841 (95% CI 0.654-1.082), and 0.875 (95% CI 0.544-1.405), 
      respectively. The outcomes of the heterogeneity tests were P=0.378 and P=0.384, 
      respectively, implying no heterogeneity. Egger-intercept outcomes were P=0.374, 
      highlighting the absence of pleiotropy. The stability of the results was affirmed 
      through the leave-one-out analysis. Notably, all F-values surpassed 10, 
      indicating the absence of weak bias attributed to instrument variables(IVs). 
      CONCLUSIONS: This research furnishes evidence supporting a causal association 
      between T2DM and male infertility. These insights offer a foundation for future 
      investigations aiming to establish the association between genetically predicted 
      T2DM and male infertility. These outcomes suggest the significance of active 
      monitoring and proactive measures for preventing infertility in male individuals 
      with T2DM. Furthermore, careful consideration is required for individuals of 
      reproductive age to prevent and treat T2DM.
CI  - Copyright (c) 2024 Fan, Zhang and Qiu.
FAU - Fan, Cuihua
AU  - Fan C
AD  - Department of Blood Transfusion, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China.
AD  - Department of Blood Transfusion, National Regional Medical Center, Binhai Campus 
      of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 
      China.
FAU - Zhang, Jiandong
AU  - Zhang J
AD  - The Center of Information, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China.
AD  - The Center of Information, National Regional Medical Center, Binhai Campus of the 
      First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
FAU - Qiu, Dongbiao
AU  - Qiu D
AD  - Department of Blood Transfusion, the First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China.
AD  - Department of Blood Transfusion, National Regional Medical Center, Binhai Campus 
      of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240311
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Male
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology/genetics
MH  - Genome-Wide Association Study
MH  - *Infertility, Male/etiology/genetics
MH  - Causality
MH  - Databases, Factual
PMC - PMC10961381
OTO - NOTNLM
OT  - GWAS
OT  - Mendelian randomization
OT  - T2DM
OT  - causal relationship
OT  - male infertility
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The reviewer ZC declared a shared affiliation with the 
      author(s) to the handling editor at the time of review.
EDAT- 2024/03/26 06:45
MHDA- 2024/03/27 06:44
PMCR- 2024/01/01
CRDT- 2024/03/26 03:44
PHST- 2023/12/17 00:00 [received]
PHST- 2024/02/26 00:00 [accepted]
PHST- 2024/03/27 06:44 [medline]
PHST- 2024/03/26 06:45 [pubmed]
PHST- 2024/03/26 03:44 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2024.1357279 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2024 Mar 11;15:1357279. doi: 
      10.3389/fendo.2024.1357279. eCollection 2024.