PMID- 38532111
OWN - NLM
STAT- MEDLINE
DCOM- 20240328
LR  - 20240329
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Mar 26
TI  - Optical coherence tomography and optical coherence tomography angiography 
      findings in optic nerve hypoplasia and their relationships with visual acuity.
PG  - 7130
LID - 10.1038/s41598-024-57118-7 [doi]
LID - 7130
AB  - This study aimed to quantitatively assess the thickness of the peripapillary 
      retinal nerve fiber layer (pRNFL) thickness, as well as the microvascular 
      alterations in the macula and peripapillary regions, in optic nerve hypoplasia 
      (ONH) patients compared to normal controls. This was achieved through the 
      utilization of spectral-domain optical coherence tomography (SD-OCT) and optical 
      coherence tomography angiography (OCTA), with a specific focus on elucidating the 
      association between these structural alterations and visual acuity. We included a 
      total of 17 eyes of 12 ONH patients, and 34 eyes of age-matched 34 healthy 
      controls. The pRNFL thickness was quantified using SD-OCT, while OCTA facilitated 
      the visualization and measurement of the microvascular structure images of the 
      superficial retinal capillary plexus (SRCP), deep retinal capillary plexus 
      (DRCP), and radial peripapillary capillary (RPC) segment in the macula and 
      peripapillary area. pRNFL thickness was measured for eight sectors (superior, 
      temporal, inferior, nasal, superotemporal, superonasal, inferotemporal, and 
      inferonasal). SRCP, DRCP, and RPC were measured for four sectors (superior, 
      temporal, inferior, and nasal). Age, gender, and spherical equivalent refractive 
      errors were statistically adjusted for the analysis. Associations of structural 
      parameters with visual acuity in ONH patients were analyzed using Spearman 
      correlation analysis. pRNFL thickness was significantly thinner in ONH patients 
      than in controls for all sectors. Vessel densities of temporal and nasal sectors 
      in DRCP were significantly higher in ONH patients, but vessel densities of the 
      inferior sector in RPC were significantly lower than those in controls. For all 
      sectors, pRNFL thickness was strongly associated with visual acuity in ONH 
      patients. ONH patients showed significant pRNFL thinning and microvascular 
      alterations compared to controls, and pRNFL thickness was strongly associated 
      with visual function. OCT and OCTA are useful tools for evaluating optic disc 
      hypoplasia and its functional status.
CI  - (c) 2024. The Author(s).
FAU - Kang, Min Chae
AU  - Kang MC
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
FAU - Park, Kyung-Ah
AU  - Park KA
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. 
      kparkoph@skku.edu.
FAU - Oh, Sei Yeul
AU  - Oh SY
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea. 
      syoh@skku.edu.
LA  - eng
GR  - NRF-2021R1A2C1007718/National Research Foundation of Korea (NRF) by MSIT/
PT  - Journal Article
DEP - 20240326
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - *Optic Disk/blood supply
MH  - *Optic Nerve Hypoplasia
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity
MH  - Angiography
MH  - Retinal Vessels
MH  - Fluorescein Angiography
PMC - PMC10965976
OTO - NOTNLM
OT  - Deep retinal capillary plexus
OT  - Intraretinal microvasculature
OT  - Optic nerve hypoplasia
OT  - Optical coherence tomography
OT  - Optical coherence tomography angiography
OT  - Radial peripapillary capillary segment
OT  - Retinal nerve fiber layer
OT  - Superficial retinal capillary plexus
COIS- The authors declare no competing interests.
EDAT- 2024/03/27 06:44
MHDA- 2024/03/28 06:45
PMCR- 2024/03/26
CRDT- 2024/03/27 00:30
PHST- 2023/10/27 00:00 [received]
PHST- 2024/03/14 00:00 [accepted]
PHST- 2024/03/28 06:45 [medline]
PHST- 2024/03/27 06:44 [pubmed]
PHST- 2024/03/27 00:30 [entrez]
PHST- 2024/03/26 00:00 [pmc-release]
AID - 10.1038/s41598-024-57118-7 [pii]
AID - 57118 [pii]
AID - 10.1038/s41598-024-57118-7 [doi]
PST - epublish
SO  - Sci Rep. 2024 Mar 26;14(1):7130. doi: 10.1038/s41598-024-57118-7.