PMID- 38532501
OWN - NLM
STAT- MEDLINE
DCOM- 20240328
LR  - 20240329
IS  - 1758-9193 (Electronic)
VI  - 16
IP  - 1
DP  - 2024 Mar 26
TI  - ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE 
      study.
PG  - 65
LID - 10.1186/s13195-024-01427-6 [doi]
LID - 65
AB  - BACKGROUND: It has been reported that the risk of Alzheimer's disease (AD) could 
      be predicted by the Australian National University Alzheimer Disease Risk Index 
      (ANU-ADRI) scores. However, among non-demented Chinese adults, the correlations 
      of ANU-ADRI scores with cerebrospinal fluid (CSF) core biomarkers and cognition 
      remain unclear. METHODS: Individuals from the Chinese Alzheimer's Biomarker and 
      LifestyLE (CABLE) study were grouped into three groups (low/intermediate/high 
      risk groups) based on their ANU-ADRI scores. The multiple linear regression 
      models were conducted to investigate the correlations of ANU-ADRI scores with 
      several biomarkers of AD pathology. Mediation model and structural equation model 
      (SEM) were conducted to investigate the mediators of the correlation between 
      ANU-ADRI scores and cognition. RESULTS: A total of 1078 non-demented elders were 
      included in our study, with a mean age of 62.58 (standard deviation [SD] 10.06) 
      years as well as a female proportion of 44.16% (n = 476). ANU-ADRI scores were 
      found to be significantly related with MMSE (beta = -0.264, P < 0.001) and MoCA 
      (beta = -0.393, P < 0.001), as well as CSF t-tau (beta = 0.236, P < 0.001), p-tau 
      (beta = 0.183, P < 0.001), and t-tau/Abeta42 (beta = 0.094, P = 0.005). Mediation analyses 
      indicated that the relationships of ANU-ADRI scores with cognitive scores were 
      mediated by CSF t-tau or p-tau (mediating proportions ranging from 4.45% to 
      10.50%). SEM did not reveal that ANU-ADRI scores affected cognition by 
      tau-related pathology and level of CSF soluble triggering receptor expressed on 
      myeloid cells 2 (sTREM2). CONCLUSION: ANU-ADRI scores were associated with 
      cognition and tau pathology. We also revealed a potential pathological mechanism 
      underlying the impact of ANU-ADRI scores on cognition.
CI  - (c) 2024. The Author(s).
FAU - Yin, Shan
AU  - Yin S
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Gao, Pei-Yang
AU  - Gao PY
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Ou, Ya-Nan
AU  - Ou YN
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Fu, Yan
AU  - Fu Y
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Wang, Zuo-Teng
AU  - Wang ZT
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Han, Bao-Lin
AU  - Han BL
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China.
FAU - Tan, Lan
AU  - Tan L
AUID- ORCID: 0000-0002-8759-7588
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 
      Donghai Middle Road, Qingdao, China. dr.tanlan@163.com.
LA  - eng
GR  - 82271475, 32300824/National Natural Science Foundation of China/
GR  - 82271475, 32300824/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20240326
PL  - England
TA  - Alzheimers Res Ther
JT  - Alzheimer's research & therapy
JID - 101511643
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Alzheimer Disease/cerebrospinal fluid
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - Australia
MH  - Biomarkers/cerebrospinal fluid
MH  - Cognition
MH  - Life Style
MH  - Peptide Fragments/cerebrospinal fluid
MH  - tau Proteins/cerebrospinal fluid
MH  - Male
PMC - PMC10964631
OTO - NOTNLM
OT  - ANU-ADRI
OT  - Alzheimer's disease
OT  - Biomarkers
OT  - Cerebrospinal fluid
COIS- The authors declare no competing interests.
EDAT- 2024/03/27 06:44
MHDA- 2024/03/28 06:45
PMCR- 2024/03/26
CRDT- 2024/03/27 01:24
PHST- 2023/12/09 00:00 [received]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/28 06:45 [medline]
PHST- 2024/03/27 06:44 [pubmed]
PHST- 2024/03/27 01:24 [entrez]
PHST- 2024/03/26 00:00 [pmc-release]
AID - 10.1186/s13195-024-01427-6 [pii]
AID - 1427 [pii]
AID - 10.1186/s13195-024-01427-6 [doi]
PST - epublish
SO  - Alzheimers Res Ther. 2024 Mar 26;16(1):65. doi: 10.1186/s13195-024-01427-6.