PMID- 38532971 OWN - NLM STAT- MEDLINE DCOM- 20240328 LR - 20240506 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Factors and pathways of non-suicidal self-injury in children: insights from computational causal analysis. PG - 1305746 LID - 10.3389/fpubh.2024.1305746 [doi] LID - 1305746 AB - BACKGROUND: Non-suicidal self-injury (NSSI) has become a significant public health issue, especially prevalent among adolescents. The complexity and multifactorial nature of NSSI necessitate a comprehensive understanding of its underlying causal factors. This research leverages the causal discovery methodology to explore these causal associations in children. METHODS: An observational dataset was scrutinized using the causal discovery method, particularly employing the constraint-based approach. By integrating machine learning and causal inference techniques, the study aimed to determine direct causal relationships associated with NSSI. The robustness of the causal relationships was evaluated using three methods to construct and validate it: the PC (Peter and Clark) method, Fast Causal Inference (FCI) method, and the GAE (Graphical Autoencoder) method. RESULTS: Analysis identified nine nodes with direct causal relationships to NSSI, including life satisfaction, depression, family dysfunction, sugary beverage consumption, PYD (positive youth development), internet addiction, COVID-19 related PTSD, academic anxiety, and sleep duration. Four principal causal pathways were identified, highlighting the roles of lockdown-induced lifestyle changes, screen time, positive adolescent development, and family dynamics in influencing NSSI risk. CONCLUSIONS: An in-depth analysis of the factors leading to Non-Suicidal Self-Injury (NSSI), highlighting the intricate connections among individual, family, and pandemic-related influences. The results, derived from computational causal analysis, underscore the critical need for targeted interventions that tackle these diverse causative factors. CI - Copyright (c) 2024 Guo, Wang, Li, Feng, Lu, Jiang and Zhao. FAU - Guo, Xinyu AU - Guo X AD - Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Wang, Linna AU - Wang L AD - College of Computer Science, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Zhenchao AU - Li Z AD - Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Feng, Ziliang AU - Feng Z AD - College of Computer Science, Sichuan University, Chengdu, Sichuan, China. FAU - Lu, Li AU - Lu L AD - College of Computer Science, Sichuan University, Chengdu, Sichuan, China. FAU - Jiang, Lihua AU - Jiang L AD - Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. AD - Teaching and Research Section of General Practice, The General Practice Medical Center, West China Hospital of Sichuan University, Chengdu, China. FAU - Zhao, Li AU - Zhao L AD - Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240312 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Adolescent MH - Child MH - Humans MH - Anxiety MH - Anxiety Disorders MH - Family Relations MH - Risk Factors MH - *Self-Injurious Behavior MH - Observation PMC - PMC10963487 OTO - NOTNLM OT - COVID-19 OT - NSSI OT - artificial intelligence OT - causal discovery OT - mental health OT - risk factors COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/03/27 06:44 MHDA- 2024/03/28 06:44 PMCR- 2024/03/12 CRDT- 2024/03/27 03:49 PHST- 2023/10/02 00:00 [received] PHST- 2024/02/23 00:00 [accepted] PHST- 2024/03/28 06:44 [medline] PHST- 2024/03/27 06:44 [pubmed] PHST- 2024/03/27 03:49 [entrez] PHST- 2024/03/12 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1305746 [doi] PST - epublish SO - Front Public Health. 2024 Mar 12;12:1305746. doi: 10.3389/fpubh.2024.1305746. eCollection 2024.