PMID- 38533017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 6
DP  - 2024 Mar 30
TI  - Associations between mixed exposure to phthalates and latent tuberculosis 
      infection among the general U.S. population from NHANES 2011-2012.
PG  - e27958
LID - 10.1016/j.heliyon.2024.e27958 [doi]
LID - e27958
AB  - BACKGROUND: People are constantly exposed to phthalates, but few reliable studies 
      have focused on the connection between phthalate exposure and latent tuberculosis 
      infection (LTBI). METHODS: Data were obtained from the National Health and 
      Nutrition Examination Survey (NHANES) database (2011-2012). The LTBI was assessed 
      by QuantiFERON(R)-TB Gold-In-Tube (QFT) or tuberculin skin testing (TST). The odds 
      ratios (ORs) and 95% confidence intervals (CIs) per log10 unit change in the 
      concentration of phthalate metabolites were calculated using crude and adjusted 
      logistic regression models. The relationships between mixed phthalate 
      concentrations and LTBI were assessed using Bayesian kernel machine regression 
      (BKMR) models. RESULTS: According to the results of the multivariable logistic 
      regression, in a fully adjusted model, only monobenzyl phthalate (MBZP) was 
      negatively associated with LTBI in Q3 (OR (95% CI): 0.485 (0.286,0.823), 
      P = 0.007). According to the restricted cubic spline (RCS) model, there was a 
      linear dose‒response association between all 11 phthalate metabolites and LTBI (p 
      for nonlinearity >0.05). We found a significant positive correlation between 
      mixed phthalate metabolites and LTBI by using fully adjusted BKMR model. 
      CONCLUSIONS: Our analysis demonstrated that LTBI in the general U.S. population 
      is linearly linked with exposure to single or combined phthalates.
CI  - (c) 2024 The Authors.
FAU - Ran, Bi
AU  - Ran B
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital and 
      Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, 
      Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, China.
FAU - Qin, Jiangyue
AU  - Qin J
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital and 
      Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, 
      Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, China.
AD  - General Practice Ward/International Medical Center Ward, General Practice Medical 
      Center, West China Hospital, Sichuan University, Chengdu, China.
FAU - Wu, Yanqiu
AU  - Wu Y
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital and 
      Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, 
      Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, China.
FAU - Wen, Fuqiang
AU  - Wen F
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital and 
      Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, 
      Sichuan University. Guoxuexiang 37, Chengdu, Sichuan, 610041, China.
LA  - eng
PT  - Journal Article
DEP - 20240315
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10963332
OTO - NOTNLM
OT  - Bayesian kernel machine regression (BKMR)
OT  - Latent tuberculosis infection
OT  - Multivariable logistic regression
OT  - NHANES
OT  - Phthalate metabolites
OT  - Restricted cubic spline (RCS)
COIS- The authors declare the following financial interests/personal relationships 
      which may be considered as potential competing interests:Fuqiang Wen reports 
      financial support was provided by 10.13039/501100013365West China Hospital of 
      10.13039/501100004912Sichuan University.
EDAT- 2024/03/27 06:44
MHDA- 2024/03/27 06:45
PMCR- 2024/03/15
CRDT- 2024/03/27 03:50
PHST- 2023/09/26 00:00 [received]
PHST- 2024/02/17 00:00 [revised]
PHST- 2024/03/08 00:00 [accepted]
PHST- 2024/03/27 06:45 [medline]
PHST- 2024/03/27 06:44 [pubmed]
PHST- 2024/03/27 03:50 [entrez]
PHST- 2024/03/15 00:00 [pmc-release]
AID - S2405-8440(24)03989-6 [pii]
AID - e27958 [pii]
AID - 10.1016/j.heliyon.2024.e27958 [doi]
PST - epublish
SO  - Heliyon. 2024 Mar 15;10(6):e27958. doi: 10.1016/j.heliyon.2024.e27958. 
      eCollection 2024 Mar 30.