PMID- 38533318
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 11
DP  - 2024
TI  - Causality between allergic diseases and kidney diseases: a two-sample Mendelian 
      randomization study.
PG  - 1347152
LID - 10.3389/fmed.2024.1347152 [doi]
LID - 1347152
AB  - BACKGROUND: Evidence from observational studies and clinical trials suggests that 
      the allergic diseases (ADs) are associated with kidney diseases (KDs). However, 
      the causal association between them remains to be determined. We used 
      bidirectional two-sample Mendelian randomization (MR) analysis to evaluate the 
      potential causality between them. METHODS: Mendelian randomization (MR) was 
      performed using publicly available genome-wide association study (GWAS) summary 
      datasets. Inverse variance weighted (IVW), weighted median, MR-Egger regression, 
      simple mode, and weighted mode methods are used to evaluate the causality between 
      ADs and KDs. Sensitivity and heterogeneity analyses were used to ensure the 
      stability of the results. RESULTS: The MR results indicated that genetic 
      susceptibility to ADs was associated with a higher risk of CKD [odds ratio (OR) = 
      1.124, 95% CI = 1.020-1.239, p = 0.019] and unspecified kidney failure (OR = 
      1.170, 95% CI = 1.004-1.363, p = 0.045) but not with kidney stone, ureter stone 
      or bladder stone (OR = 1.001, 95% CI = 1.000-1.002, p = 0.216), other renal or 
      kidney problem (OR = 1.000, 95% CI = 1.000-1.001, p = 0.339), urinary tract or 
      kidney infection (OR = 1.000, 95% CI = 0.999-1.001, p = 0.604), kidney volume (OR 
      = 0.996, 95% CI = 0.960-1.033, p = 0.812) and cyst of kidney (OR = 0.914, 95% CI 
      = 0.756-1.105, p = 0.354). No causal evidence of KDs on ADs was found in present 
      study. CONCLUSION: Results from MR analysis indicate a causal association between 
      ADs and CKD and unspecified kidney failure. These findings partly suggest that 
      early monitoring of CKD risk in patients with ADs is intentional.
CI  - Copyright (c) 2024 Peng, Dong, Long, Li, Wang, Zhu and Ding.
FAU - Peng, Zhe
AU  - Peng Z
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
FAU - Dong, Xinyu
AU  - Dong X
AD  - Science and Technology Innovation Center, Guangzhou University of Chinese 
      Medicine, Guangzhou, Guangdong, China.
FAU - Long, Yingxin
AU  - Long Y
AD  - College of Pharmacy, Jinan University, Guangzhou, Guangdong, China.
FAU - Li, Zunjiang
AU  - Li Z
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
FAU - Wang, Yueyao
AU  - Wang Y
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
FAU - Zhu, Wei
AU  - Zhu W
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
FAU - Ding, Banghan
AU  - Ding B
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
AD  - Guangdong Provincial Key Laboratory of Research on Emergency in Traditional 
      Chinese Medicine, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20240312
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10963543
OTO - NOTNLM
OT  - GWAS
OT  - Mendelian randomization
OT  - allergic diseases
OT  - causality
OT  - kidney diseases
OT  - reverse-direction
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/27 06:44
MHDA- 2024/03/27 06:45
PMCR- 2024/03/12
CRDT- 2024/03/27 03:55
PHST- 2023/12/07 00:00 [received]
PHST- 2024/02/29 00:00 [accepted]
PHST- 2024/03/27 06:45 [medline]
PHST- 2024/03/27 06:44 [pubmed]
PHST- 2024/03/27 03:55 [entrez]
PHST- 2024/03/12 00:00 [pmc-release]
AID - 10.3389/fmed.2024.1347152 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2024 Mar 12;11:1347152. doi: 10.3389/fmed.2024.1347152. 
      eCollection 2024.