PMID- 38534759
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 46
IP  - 3
DP  - 2024 Mar 9
TI  - The Beneficial Role of Lactobacillus paracasei subsp. paracasei NTU 101 in the 
      Prevention of Atopic Dermatitis.
PG  - 2236-2250
LID - 10.3390/cimb46030143 [doi]
AB  - Atopic dermatitis (AD) is a recurrent allergic disease characterized by symptoms 
      such as itching, redness, swelling, dryness, scaling skin, inflammation, and 
      tissue damage. The underlying pathogenesis of AD remains unclear. Steroid drugs 
      are commonly used in the clinical treatment of AD; however, their long-term use 
      may lead to associated complications. Numerous studies have indicated that 
      probiotics could modulate the immune system, enhance immune function, or suppress 
      excessive immune responses. In this study, Lactobacillus paracasei subsp. 
      paracasei NTU 101 (NTU 101) was orally administered for a duration of 4 weeks, 
      followed by the induction of AD using ovalbumin (OVA) in a mouse model. The skin 
      condition of the stimulated site was observed during the induction period. 
      Subsequently, the serum immunoglobulin E (IgE) content, splenocyte T cell typing, 
      and skin histological interpretation were examined to evaluate the efficacy of 
      NTU 101 in alleviating AD symptoms in allergen-exposed animals. The findings 
      indicated that administering NTU 101 beforehand effectively alleviated skin 
      symptoms in animals with AD. It reduced the infiltration of inflammatory cells in 
      skin tissue sections, and compared to the OVA group, there was a significant 
      reduction in the thickening of the epidermal cell layer (decreased from 89.0 +/- 
      20.2 microM to 48.6 +/- 16.0 microM) and dermis layer (decreased from 310.3 +/- 69.0 microM to 
      209.7 +/- 55.5 microM). Moreover, the proportion of regulatory T (Treg) cells and T 
      helper 2 (Th2) cells in splenocytes significantly increased, while the 
      proportions of T helper 1 (Th1) and T helper 17 (Th17) cells did not differ. It 
      is speculated that the potential mechanism by which NTU 101 prevents AD involves 
      increasing the expression of Forkhead box protein P3 (FOXP3) and promoting Treg 
      cell maturation, thereby alleviating allergic reaction symptoms associated with 
      AD.
FAU - Liu, Chin-Feng
AU  - Liu CF
AD  - Continuing Education Program of Food Biotechnology Applications, National Taitung 
      University, 684, Sec. 1, Zhonghua Rd.,Taitung 950017, Taiwan.
FAU - Shih, Tsung-Wei
AU  - Shih TW
AD  - SunWay Biotech Co., Taipei 10617, Taiwan.
FAU - Lee, Chun-Lin
AU  - Lee CL
AUID- ORCID: 0000-0002-0203-9465
AD  - Department of Life Science, National Taitung University, 369, Sec. 2, University 
      Rd., Taitung 95092, Taiwan.
FAU - Pan, Tzu-Ming
AU  - Pan TM
AUID- ORCID: 0000-0002-9865-1893
AD  - SunWay Biotech Co., Taipei 10617, Taiwan.
AD  - Department of Biochemical Science and Technology, National Taiwan University, 
      Taipei 10617, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20240309
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
PMC - PMC10968845
OTO - NOTNLM
OT  - NTU 101
OT  - allergic reaction
OT  - atopic dermatitis
COIS- Authors T.-W.S. and T.-M.P. were employed by the company SunWay Biotech Co. The 
      remaining authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/27 12:45
MHDA- 2024/03/27 12:46
PMCR- 2024/03/09
CRDT- 2024/03/27 09:26
PHST- 2024/02/06 00:00 [received]
PHST- 2024/02/29 00:00 [revised]
PHST- 2024/03/07 00:00 [accepted]
PHST- 2024/03/27 12:46 [medline]
PHST- 2024/03/27 12:45 [pubmed]
PHST- 2024/03/27 09:26 [entrez]
PHST- 2024/03/09 00:00 [pmc-release]
AID - cimb46030143 [pii]
AID - cimb-46-00143 [pii]
AID - 10.3390/cimb46030143 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2024 Mar 9;46(3):2236-2250. doi: 10.3390/cimb46030143.