PMID- 38536862
OWN - NLM
STAT- MEDLINE
DCOM- 20240409
LR  - 20240409
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 10
IP  - 4
DP  - 2024 Apr 8
TI  - Ultrastable Iodinated Oil-Based Pickering Emulsion Enables Locoregional Sustained 
      Codelivery of Hypoxia Inducible Factor-1 Inhibitor and Anticancer Drugs for Tumor 
      Combination Chemotherapy.
PG  - 2270-2281
LID - 10.1021/acsbiomaterials.3c01887 [doi]
AB  - Tumor hypoxia-associated drug resistance presents a major challenge for cancer 
      chemotherapy. However, sustained delivery systems with a high loading capability 
      of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we 
      developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve 
      locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an 
      anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE 
      exhibited facile injectability for intratumoral administration, great radiopacity 
      for in vivo examination, excellent physical stability (>1 mo), and long-term 
      sustained release capability of both hydrophilic drugs (i.e., acriflavine and 
      doxorubicin). We found that the codelivery of acriflavine and doxorubicin from 
      the PE promoted the local accumulation and retention of both drugs using an 
      acellular liver organ model and demonstrated significant inhibition of tumor 
      growth in a 4T1 tumor-bearing mouse model, improving the chemotherapeutic 
      efficacy through the synergistic effects of direct cytotoxicity with the 
      functional suppression of HIF-1 pathways of tumor cells. Such an iodinated 
      oil-based PE provides a great injectable sustained delivery platform of 
      hydrophilic drugs for locoregional chemotherapy.
FAU - Li, Zhihua
AU  - Li Z
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Liu, Xiaoya
AU  - Liu X
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Xiao, Jingyu
AU  - Xiao J
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Jiang, Hang
AU  - Jiang H
AD  - Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, 
      School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, 
      China.
FAU - Ma, Le
AU  - Ma L
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Luo, Yucheng
AU  - Luo Y
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Wang, Meijuan
AU  - Wang M
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Zhu, Yuwei
AU  - Zhu Y
AD  - Department of Chemistry, The Chinese University of Hong Kong, Shatin, New 
      Territories, Hong Kong 999077, PR China.
FAU - Jiang, Hongliang
AU  - Jiang H
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Yao, Hanyang
AU  - Yao H
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
FAU - Ngai, To
AU  - Ngai T
AUID- ORCID: 0000-0002-7207-6878
AD  - Department of Chemistry, The Chinese University of Hong Kong, Shatin, New 
      Territories, Hong Kong 999077, PR China.
FAU - Guo, Qiongyu
AU  - Guo Q
AUID- ORCID: 0000-0002-1916-9100
AD  - Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key 
      Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, 
      Southern University of Science and Technology, Shenzhen 518055, China.
LA  - eng
PT  - Journal Article
DEP - 20240327
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
RN  - 0 (Emulsions)
RN  - 1T3A50395T (Acriflavine)
RN  - 0 (Antineoplastic Agents)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Emulsions/therapeutic use
MH  - Acriflavine/pharmacology/therapeutic use
MH  - *Antineoplastic Agents/pharmacology/therapeutic use
MH  - *Neoplasms/drug therapy
MH  - Doxorubicin/pharmacology/therapeutic use
MH  - Drug Therapy, Combination
MH  - Hypoxia/drug therapy
OTO - NOTNLM
OT  - Pickering emulsion
OT  - drug delivery
OT  - hypoxia
OT  - iodinated oil
OT  - locoregional chemotherapy
EDAT- 2024/03/27 18:45
MHDA- 2024/04/09 06:45
CRDT- 2024/03/27 13:52
PHST- 2024/04/09 06:45 [medline]
PHST- 2024/03/27 18:45 [pubmed]
PHST- 2024/03/27 13:52 [entrez]
AID - 10.1021/acsbiomaterials.3c01887 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2024 Apr 8;10(4):2270-2281. doi: 
      10.1021/acsbiomaterials.3c01887. Epub 2024 Mar 27.