PMID- 38537321
OWN - NLM
STAT- MEDLINE
DCOM- 20240419
LR  - 20240419
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 296
DP  - 2024 May
TI  - Plasma and peritoneal fluid cytokine profiles in patient with Essure(R) implant: 
      Towards a molecular signature?
PG  - 349-353
LID - S0301-2115(24)00153-2 [pii]
LID - 10.1016/j.ejogrb.2024.03.031 [doi]
AB  - OBJECTIVE(S): Many patients with Essure(R) implant may experience adverse events 
      related to the device. Although local inflammation does not appear to be the 
      pathophysiological mechanism underlying the symptoms, systemic inflammation could 
      play a role. In the present study, as cytokines are involved in the inflammatory 
      process, we proposed to investigate the profile of circulating and peritoneal 
      cytokines. STUDY DESIGN: In this retrospective study, we evaluated the levels of 
      cytokines in peritoneal fluid (PF) as well as in plasma sample from three 
      different groups: Essure(R) group, endometriosis group (known to be associated with 
      immune dysregulation), and control group. RESULTS: There were 60 symptomatic 
      patients with Essure(R) device, 30 patients with endometriosis and a control group 
      of 30 patients. The PF levels of Interleukin-10 (IL-10), Interleukin-6 (IL-6), 
      and Monocyte chemoattractant protein-1 (MCP-1) were statistically higher in 
      endometriosis group than in Essure(R) group and control group. The plasma level of 
      MCP-1 was higher in Essure(R) group than in endometriosis group and control group. 
      The plasma level of TNF-alpha was higher in Essure(R) group than in control group. 
      CONCLUSIONS: The chemokine MCP-1 as well as the pro-inflammatory TNF-alpha, are known 
      to be increased in patients with fibromyalgia and chronic fatigue syndrome. Since 
      patients with Essure(R) may exhibit symptoms similar to fibromyalgia, MCP-1 and 
      TNF-alpha may be relevant markers in symptomatic patients with Essure(R). Because of 
      the lack of longitudinal data (no evaluation of postoperative cytokine profile 
      and no assessment of the level of clinical improvement), other studies are needed 
      to confirm these preliminary results.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Garnier, Lorna
AU  - Garnier L
AD  - Immunology Laboratory, Hopital Lyon-Sud, Hospices Civils de Lyon, Chemin du 
      Grand-Revoyet, University hospital of Lyon, 69495 Pierre-Benite, France.
FAU - Parant, Francois
AU  - Parant F
AD  - Trace Element Analysis Laboratory, Biochemistry Department, CBAPS, Centre 
      hospitalier Lyon-Sud, Chemin du Grand-Revoyet, University hospital of Lyon, 69495 
      Pierre-Benite, France.
FAU - Bulteau, Claire
AU  - Bulteau C
AD  - Immunology Laboratory, Hopital Lyon-Sud, Hospices Civils de Lyon, Chemin du 
      Grand-Revoyet, University hospital of Lyon, 69495 Pierre-Benite, France.
FAU - Pescarmona, Remi
AU  - Pescarmona R
AD  - Immunology Laboratory, Hopital Lyon-Sud, Hospices Civils de Lyon, Chemin du 
      Grand-Revoyet, University hospital of Lyon, 69495 Pierre-Benite, France.
FAU - Cerruto, Emanuele
AU  - Cerruto E
AD  - Department of Gynecology, Hopital Femme Mere Enfant, HFME, 59 boulevard Pinel, 
      University hospital of Lyon, 69500 Bron, France.
FAU - Moret, Stephanie
AU  - Moret S
AD  - Department of Gynecology, Hopital Femme Mere Enfant, HFME, 59 boulevard Pinel, 
      University hospital of Lyon, 69500 Bron, France.
FAU - Miguet-Bensouda, Chloe
AU  - Miguet-Bensouda C
AD  - Department of Gynecology, Hopital Femme Mere Enfant, HFME, 59 boulevard Pinel, 
      University hospital of Lyon, 69500 Bron, France.
FAU - Nohuz, Erdogan
AU  - Nohuz E
AD  - Department of Gynecology, Hopital Femme Mere Enfant, HFME, 59 boulevard Pinel, 
      University hospital of Lyon, 69500 Bron, France.
FAU - Chene, Gautier
AU  - Chene G
AD  - Department of Gynecology, Hopital Femme Mere Enfant, HFME, 59 boulevard Pinel, 
      University hospital of Lyon, 69500 Bron, France; University Claude Bernard of 
      Lyon 1, EMR 3738 CICLY, 69000 Lyon, France. Electronic address: 
      chenegautier@yahoo.fr.
LA  - eng
PT  - Journal Article
DEP - 20240326
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Female
MH  - Humans
MH  - Tumor Necrosis Factor-alpha
MH  - *Endometriosis
MH  - Retrospective Studies
MH  - Ascitic Fluid
MH  - *Fibromyalgia
MH  - Cytokines
MH  - Interleukin-6
MH  - Inflammation
OTO - NOTNLM
OT  - Cytokines
OT  - Essure(R) removal
OT  - Heavy metal
OT  - Inflammation
OT  - Metal trace element
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/28 00:45
MHDA- 2024/04/19 06:43
CRDT- 2024/03/27 19:00
PHST- 2024/01/13 00:00 [received]
PHST- 2024/03/19 00:00 [revised]
PHST- 2024/03/24 00:00 [accepted]
PHST- 2024/04/19 06:43 [medline]
PHST- 2024/03/28 00:45 [pubmed]
PHST- 2024/03/27 19:00 [entrez]
AID - S0301-2115(24)00153-2 [pii]
AID - 10.1016/j.ejogrb.2024.03.031 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2024 May;296:349-353. doi: 
      10.1016/j.ejogrb.2024.03.031. Epub 2024 Mar 26.