PMID- 38538689
OWN - NLM
STAT- MEDLINE
DCOM- 20240329
LR  - 20240330
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Mar 27
TI  - Development of a formula for estimated glomerular filtration rate in pregnant 
      women from physiological hyperfiltration of serum creatinine.
PG  - 7229
LID - 10.1038/s41598-024-57737-0 [doi]
LID - 7229
AB  - Increased body fluids during pregnancy complicates the application of estimated 
      glomerular filtration rate (eGFR) formulas that are based on body surface area. 
      Furthermore, gestational renal dysfunction cannot be identified if the serum 
      creatinine (SCr) concentration is within the non-pregnant reference interval (RI) 
      despite inadequate pregnancy-related renal hyperfiltration. 1484 SCr measurements 
      from 957 healthy pregnant women were collected. The average SCr value of 
      gestational week (GW) 0-3 was the representative SCr value of non-pregnant 
      status. While the distribution of SCr measurements varied across GWs, it was 
      transformed into a normal distribution using the bootstrap resampling method. A 
      polynomial linear regression method was applied to achieve a continuous and 
      smooth transformation of values. The normally distributed SCr values of each GW 
      were compared to the non-pregnant status, leading to the calculation of SCr 
      hyperfiltration. The final equation, (2 - SCr (mumol/L) / 55.25)  x  103.1  x  
      55.25/(56.7 - 0.223  x  GW - 0.113  x  GW(2) +  0.00545  x  GW(3) - 0.0000653  x  
      GW(4)), and reference intervals for both SCr and eGFR for each GW were obtained. 
      These RIs and novel equations can be effectively used to monitor renal 
      dysfunction in pregnant women.
CI  - (c) 2024. The Author(s).
FAU - Ahn, Kwangjin
AU  - Ahn K
AD  - Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, 
      Wonju-si, Republic of Korea.
FAU - Lee, Taesic
AU  - Lee T
AD  - Department of Family Medicine, Yonsei University Wonju College of Medicine, 
      Wonju-si, Republic of Korea.
FAU - Kang, Jieun
AU  - Kang J
AD  - Department of Obstetrics and Gynecology, Yonsei University Wonju College of 
      Medicine, Wonju-si, Republic of Korea.
FAU - Choi, Seong Jin
AU  - Choi SJ
AD  - Department of Obstetrics and Gynecology, Yonsei University Wonju College of 
      Medicine, Wonju-si, Republic of Korea.
FAU - Hwang, Sangwon
AU  - Hwang S
AD  - Department of Precision Medicine, Yonsei University Wonju College of Medicine, 
      Wonju-si, Republic of Korea.
FAU - Seo, Dong Min
AU  - Seo DM
AD  - Department of Medical Information, Yonsei University Wonju College of Medicine, 
      Wonju-si, Republic of Korea.
FAU - Cho, Jooyoung
AU  - Cho J
AD  - Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, 
      Wonju-si, Republic of Korea.
FAU - Uh, Young
AU  - Uh Y
AUID- ORCID: 0000-0002-2879-7870
AD  - Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, 
      Wonju-si, Republic of Korea. u931018@yonsei.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20240327
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Creatinine
MH  - *Pregnant Women
MH  - Kidney
MH  - *Kidney Diseases
PMC - PMC10973345
COIS- The authors declare no competing interests.
EDAT- 2024/03/28 06:46
MHDA- 2024/03/29 06:45
PMCR- 2024/03/27
CRDT- 2024/03/28 00:22
PHST- 2023/12/21 00:00 [received]
PHST- 2024/03/21 00:00 [accepted]
PHST- 2024/03/29 06:45 [medline]
PHST- 2024/03/28 06:46 [pubmed]
PHST- 2024/03/28 00:22 [entrez]
PHST- 2024/03/27 00:00 [pmc-release]
AID - 10.1038/s41598-024-57737-0 [pii]
AID - 57737 [pii]
AID - 10.1038/s41598-024-57737-0 [doi]
PST - epublish
SO  - Sci Rep. 2024 Mar 27;14(1):7229. doi: 10.1038/s41598-024-57737-0.