PMID- 38539024
OWN - NLM
STAT- Publisher
LR  - 20240328
IS  - 1534-312X (Electronic)
IS  - 1522-8037 (Linking)
DP  - 2024 Mar 28
TI  - Esophagogastric Junction Outflow Obstruction (EGJOO): A Manometric Phenomenon or 
      Clinically Impactful Problem.
LID - 10.1007/s11894-024-00928-6 [doi]
AB  - PURPOSE OF REVIEW: Esophagogastric junction outflow obstruction (EGJOO), defined 
      manometrically by impaired esophagogastric junction relaxation (EGJ) with 
      preserved peristalsis, can be artifactual, due to secondary etiologies 
      (mechanical, medication-induced), or a true motility disorder. The purpose of 
      this review is to go over the evolving approach to diagnosing and treating 
      clinically relevant EGJOO. RECENT FINDINGS: Timed barium esophagram (TBE) and the 
      functional lumen imaging probe (FLIP) are useful to identify clinically relevant 
      EGJOO that merits lower esophageal sphincter (LES) directed therapies. There are 
      no randomized controlled trials evaluating EJGOO treatment. Uncontrolled trials 
      show effectiveness for pneumatic dilation and peroral endoscopic myotomy to treat 
      confirmed EGJOO; Botox and Heller myotomy may also be considered but data for 
      confirmed EGJOO is more limited. Diagnosis of clinically relevant idiopathic 
      EGJOO requires symptoms, exclusion of mechanical and medication-related 
      etiologies, and confirmation of EGJ obstruction by TBE or FLIP. Botox LES 
      injection has limited durability, it can be used in patients who are not 
      candidates for other treatments. PD and POEM are effective in confirmed EGJOO, 
      Heller myotomy may also be considered but data for confirmed EGJOO is limited. 
      Randomized controlled trials are needed to clarify optimal management of EGJOO.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Bach, Laura
AU  - Bach L
AD  - Mayo Clinic Arizona, 13400 E. Shea Blvd, Scottsdale, AZ, USA.
FAU - Vela, Marcelo F
AU  - Vela MF
AD  - Mayo Clinic Arizona, 13400 E. Shea Blvd, Scottsdale, AZ, USA. 
      vela.marcelo@mayo.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240328
PL  - United States
TA  - Curr Gastroenterol Rep
JT  - Current gastroenterology reports
JID - 100888896
SB  - IM
OTO - NOTNLM
OT  - Chicago Classification
OT  - EGJOO
OT  - Esophagogastric junction outflow obstruction
OT  - FLIP
OT  - Functional lumen imaging probe
OT  - High resolution esophageal manometry
OT  - TBE
OT  - Timed barium esophagram
EDAT- 2024/03/28 06:45
MHDA- 2024/03/28 06:45
CRDT- 2024/03/28 00:39
PHST- 2024/03/11 00:00 [accepted]
PHST- 2024/03/28 06:45 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 00:39 [entrez]
AID - 10.1007/s11894-024-00928-6 [pii]
AID - 10.1007/s11894-024-00928-6 [doi]
PST - aheadofprint
SO  - Curr Gastroenterol Rep. 2024 Mar 28. doi: 10.1007/s11894-024-00928-6.