PMID- 38539102 OWN - NLM STAT- MEDLINE DCOM- 20240329 LR - 20240330 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 24 IP - 1 DP - 2024 Mar 27 TI - Correlation between the cardiometabolic index and arteriosclerosis in patients with type 2 diabetes mellitus. PG - 186 LID - 10.1186/s12872-024-03853-8 [doi] LID - 186 AB - BACKGROUND: The cardiometabolic index (CMI) is a new metric derived from the triglyceride-glucose index and body mass index and is considered a potential marker for cardiovascular risk assessment. This study aimed to examine the correlation between the CMI and the presence and severity of arteriosclerosis in patients with type 2 diabetes mellitus (T2DM). METHODS: This study involved 2243 patients with T2DM. The CMI was derived by dividing the triglyceride level (mmol/L) by the high-density lipoprotein level (mmol/L) and then multiplying the quotient by the waist-to-height ratio. Multivariate logistic regression was used to analyze the correlations between the CMI and BMI blood biomarkers, blood pressure, and brachial-ankle pulse wave velocity (baPWV). RESULTS: Patients were categorized into three groups based on their CMI: Group C1 (CMI < 0.775; n = 750), Group C2 (CMI: 0.775-1.355; n = 743), and Group C3 (CMI > 1.355; n = 750). Increased BMI, fasting glucose, insulin (at 120 min), total cholesterol (TC), and baPWV values were observed in Groups C2 and C3, with statistically significant trends (all trends P < 0.05). The CMI was positively correlated with systolic blood pressure (r = 0.74, P < 0.001). Multivariate analysis revealed that an increased CMI contributed to a greater risk for arteriosclerosis (OR = 1.87, 95%CI: 1.66-2.10, P < 0.001). Compared to the C1 group, the C2 group and C3 group had a greater risk of developing arteriosclerosis, with ORs of 4.55 (95%CI: 3.57-5.81, P<0.001) and 5.56 (95%CI: 4.32-7.17, P<0.001), respectively. The association was notably stronger in patients with a BMI below 21.62 kg/m(2) than in those with a BMI of 21.62 kg/m(2) or higher (OR = 4.53 vs. OR = 1.59). CONCLUSIONS: These findings suggest that the CMI is a relevant and independent marker of arteriosclerosis in patients with T2DM and may be useful in the risk stratification and management of these patients. CI - (c) 2024. The Author(s). FAU - Tang, Chaoyan AU - Tang C AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Pang, Tianjiao AU - Pang T AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Dang, Chaozhi AU - Dang C AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Liang, Hui AU - Liang H AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Wu, Junfeng AU - Wu J AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Shen, Xiaofang AU - Shen X AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Wang, Lielin AU - Wang L AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Luo, Ruiqiong AU - Luo R AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. FAU - Lan, Haiyun AU - Lan H AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. doctorlhy@126.com. FAU - Zhang, Ping AU - Zhang P AD - Department of Endocrinology, Yulin First People's Hospital, Sixth Affiliated Hospital of Guangxi Medical University, No.495, Education Middle Road, Yulin, 537000, Guangxi Zhuang Autonomous Region, China. ylzhangping@163.com. LA - eng GR - 202324107/Scientific Research and Technology Development Program of Yulin City/ PT - Journal Article DEP - 20240327 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0 (Triglycerides) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/complications/diagnosis MH - Ankle Brachial Index MH - Risk Factors MH - Pulse Wave Analysis MH - *Arteriosclerosis/diagnosis MH - Body Mass Index MH - Triglycerides MH - Glucose PMC - PMC10976822 OTO - NOTNLM OT - Arteriosclerosis OT - Cardiometabolic Index OT - Cardiovascular Risk OT - Type 2 Diabetes Mellitus COIS- The authors declare no competing interests. EDAT- 2024/03/28 06:45 MHDA- 2024/03/29 06:46 PMCR- 2024/03/27 CRDT- 2024/03/28 00:45 PHST- 2023/12/20 00:00 [received] PHST- 2024/03/21 00:00 [accepted] PHST- 2024/03/29 06:46 [medline] PHST- 2024/03/28 06:45 [pubmed] PHST- 2024/03/28 00:45 [entrez] PHST- 2024/03/27 00:00 [pmc-release] AID - 10.1186/s12872-024-03853-8 [pii] AID - 3853 [pii] AID - 10.1186/s12872-024-03853-8 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2024 Mar 27;24(1):186. doi: 10.1186/s12872-024-03853-8.