PMID- 38539331
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 11
IP  - 3
DP  - 2024 Mar 1
TI  - Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic 
      Review of Randomized Controlled Trials.
LID - 10.3390/children11030296 [doi]
LID - 296
AB  - This systematic review was conducted with the objective of understanding the 
      efficacy and safety of proton pump inhibitors (PPIs) in the pediatric population. 
      We used PubMed to identify randomized controlled trials (RCTs) published between 
      1 June 2010 and 30 June 2023, performed in patients from birth to 18 years old 
      with gastroesophageal reflux disease (GERD) who received treatment with any PPI. 
      This literature search yielded 76 articles and 13 of these met the inclusion 
      criteria. For infants, PPIs were equal to placebos in reducing GERD symptoms in 
      four articles. In one article, the numbers of GER episodes and esophageal acid 
      exposures were lower in infants who received PPIs in the left lateral position, 
      but there was generally no significant improvement in symptoms. In another 
      publication, the combination of PPIs and feeding modifications (FMs) was not more 
      effective than PPIs alone. For children and adolescents, PPIs were effective in 
      improving symptoms and achieving endoscopic healing, which was subsequently 
      maintained. To conclude, PPIs are not effective in reducing the symptoms related 
      to GERD in infants but are effective in older children, where histological 
      remission can be seen. Generally, PPIs are well tolerated, but it is important to 
      remember the possible adverse events (AEs), especially if PPIs are used for an 
      extended period.
FAU - Fernandez-Gonzalez, Sara Maria
AU  - Fernandez-Gonzalez SM
AUID- ORCID: 0000-0002-9255-5198
AD  - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of 
      Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A 
      Coruna, Spain.
FAU - Moreno-Alvarez, Ana
AU  - Moreno-Alvarez A
AUID- ORCID: 0000-0002-7211-1821
AD  - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of 
      Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A 
      Coruna, Spain.
FAU - Solar-Boga, Alfonso
AU  - Solar-Boga A
AUID- ORCID: 0000-0003-2606-3790
AD  - Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of 
      Pediatrics, A Coruna University Hospital, Area Sanitaria A Coruna-Cee, 15006 A 
      Coruna, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240301
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10969042
OTO - NOTNLM
OT  - efficacy
OT  - gastroesophageal reflux disease
OT  - pediatric patients
OT  - proton pump inhibitors
OT  - safety
OT  - systematic review
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:44
MHDA- 2024/03/28 06:45
PMCR- 2024/03/01
CRDT- 2024/03/28 01:01
PHST- 2024/01/28 00:00 [received]
PHST- 2024/02/25 00:00 [revised]
PHST- 2024/02/27 00:00 [accepted]
PHST- 2024/03/28 06:45 [medline]
PHST- 2024/03/28 06:44 [pubmed]
PHST- 2024/03/28 01:01 [entrez]
PHST- 2024/03/01 00:00 [pmc-release]
AID - children11030296 [pii]
AID - children-11-00296 [pii]
AID - 10.3390/children11030296 [doi]
PST - epublish
SO  - Children (Basel). 2024 Mar 1;11(3):296. doi: 10.3390/children11030296.