PMID- 38539409
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 11
IP  - 3
DP  - 2024 Mar 21
TI  - Off-Label Yellow Fever and Hepatitis A Vaccination in Traveling Children.
LID - 10.3390/children11030374 [doi]
LID - 374
AB  - There are few data on yellow fever (YF) and hepatitis A (HA) off-label 
      vaccination. Given the rising trend of travel to endemic countries, there is a 
      growing necessity to broaden vaccination coverage among the pediatric population. 
      For this reason, we aim to assess the adverse effects associated with off-label 
      vaccination, with the ultimate purpose of expanding the vaccine spectrum. We 
      analyzed ambispectively ninety-four children under 12 months of age who received 
      YF or HA off-label vaccines. The YF vaccine was administered to children aged 6-9 
      months and those allergic to eggs (with a prior negative prick test and no 
      history of anaphylaxis), while the HA vaccine was given to children aged 6-12 
      months. Overall, 71 (75%) were vaccinated against YF, and 57 (60%) against HA; 34 
      against both. All of them fulfilled off-label vaccination criteria. No immediate 
      adverse effects (AEs) were reported. Mild common AEs (diarrhea, fever, or 
      malaise) were experienced by 10.8% of patients within 10 days after vaccination. 
      The rate of AEs associated with off-label vaccination for HA and YF is low, 
      suggesting that the vaccines could be considered safe.
FAU - Muruzabal, Cecilia
AU  - Muruzabal C
AUID- ORCID: 0009-0004-4301-096X
AD  - Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 
      Madrid, Spain.
FAU - Vicente, Lorea
AU  - Vicente L
AUID- ORCID: 0000-0002-3723-4885
AD  - Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 
      Madrid, Spain.
FAU - Escolano Taravillo, Lucia
AU  - Escolano Taravillo L
AUID- ORCID: 0000-0002-6317-0336
AD  - Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 
      Madrid, Spain.
FAU - Bravo Queipo de Llano, Blanca
AU  - Bravo Queipo de Llano B
AUID- ORCID: 0000-0001-8432-0703
AD  - Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 
      Madrid, Spain.
AD  - La Paz Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
FAU - Calvo, Cristina
AU  - Calvo C
AUID- ORCID: 0000-0002-6503-3423
AD  - Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 
      Madrid, Spain.
AD  - La Paz Institute for Health Research (IdiPAZ), 28029 Madrid, Spain.
AD  - Biomedical Research Network Centre for Infectious Diseases (CIBERINFEC), Carlos 
      III Health Institute, 28029 Madrid, Spain.
AD  - Translational Research Network in Pediatric Infectious Diseases (RITIP), 28046 
      Madrid, Spain.
FAU - Garcia Lopez Hortelano, Milagros
AU  - Garcia Lopez Hortelano M
AUID- ORCID: 0000-0002-5028-1029
AD  - Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 
      Madrid, Spain.
AD  - Biomedical Research Network Centre for Infectious Diseases (CIBERINFEC), Carlos 
      III Health Institute, 28029 Madrid, Spain.
AD  - Pediatric Tropical Diseases Unit, International Adoption and Consultation of 
      Traveling Children, La Paz University Hospital, 28046 Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20240321
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10969183
OTO - NOTNLM
OT  - adverse effects
OT  - hepatitis A
OT  - off-label
OT  - vaccine
OT  - yellow fever
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:45
MHDA- 2024/03/28 06:46
PMCR- 2024/03/21
CRDT- 2024/03/28 01:01
PHST- 2024/02/21 00:00 [received]
PHST- 2024/03/14 00:00 [revised]
PHST- 2024/03/18 00:00 [accepted]
PHST- 2024/03/28 06:46 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 01:01 [entrez]
PHST- 2024/03/21 00:00 [pmc-release]
AID - children11030374 [pii]
AID - children-11-00374 [pii]
AID - 10.3390/children11030374 [doi]
PST - epublish
SO  - Children (Basel). 2024 Mar 21;11(3):374. doi: 10.3390/children11030374.