PMID- 38539471
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 16
IP  - 6
DP  - 2024 Mar 13
TI  - Impact of Center Volume on Cardiopulmonary and Mortality Outcomes after 
      Immune-Checkpoint Inhibitors for Cancer: A Systematic Review and Meta-Analysis.
LID - 10.3390/cancers16061136 [doi]
LID - 1136
AB  - Immune-checkpoint inhibitors (ICIs) were proven effective in inducing tumor 
      regression. However, its toxicity tends to be fatal. We sought to investigate the 
      hospital volume/outcomes relationship. Databases were searched for studies 
      reporting immune-checkpoint inhibitors adverse events (AEs) in patients with 
      solid-organ malignancies. The outcomes were A) the pooled events rate (PER) of 
      grade 5, grade 3-4, cardiac-related, and pulmonary-related AEs, and B) the 
      assessment of the volume/outcomes relationship. One hundred and forty-seven 
      studies met our inclusion criteria. The PER of grade 5, grade 3-4, and any-grade 
      AEs was 2.75% (95%CI: 2.18-3.47), 26.69% (95%CI: 21.60-32.48), and 77.80% (95%CI: 
      70.91-83.44), respectively. The PER of pulmonary-related AEs was 4.56% (95%CI: 
      3.76-5.53). A higher number of annual cases per center was significantly 
      associated with reduced grade 5 (p = 0.019), grade 3-4 (p = 0.004), and 
      cardiac-related AEs (p = 0.035) in the meta-regression. In the current era of 
      cancer immunotherapy, knowledge regarding the early diagnosis and management of 
      immunotherapy-related AEs is essential. Our meta-analysis demonstrates the 
      importance of center volume in improving outcomes and reducing the incidence of 
      severe AEs.
FAU - Rahouma, Mohamed
AU  - Rahouma M
AUID- ORCID: 0000-0002-8678-2060
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
AD  - Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo 
      11796, Egypt.
FAU - Mynard, Nathan
AU  - Mynard N
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
FAU - Baudo, Massimo
AU  - Baudo M
AUID- ORCID: 0000-0003-3754-6704
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
AD  - Department of Cardiac Surgery, Spedali Civili di Brescia, 25123 Brescia, Italy.
FAU - Khairallah, Sherif
AU  - Khairallah S
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
AD  - Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo 
      11796, Egypt.
FAU - Al-Thani, Shaikha
AU  - Al-Thani S
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
FAU - Dabsha, Anas
AU  - Dabsha A
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
AD  - Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo 
      11796, Egypt.
FAU - Shmushkevich, Shon
AU  - Shmushkevich S
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
FAU - Shoeib, Osama
AU  - Shoeib O
AUID- ORCID: 0000-0002-8161-1457
AD  - Department of Cardiology, Tanta University, Tanta 31512, Egypt.
FAU - Hossny, Mohamed
AU  - Hossny M
AUID- ORCID: 0000-0001-8474-8785
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
FAU - Eldeeb, Elsayed
AU  - Eldeeb E
AD  - E H Reliable Medical PC, Lutheran NYU Langone, New York, NY 11214, USA.
FAU - Aziz, Hala
AU  - Aziz H
AUID- ORCID: 0000-0003-4864-2224
AD  - Medical Oncology Department, National Cancer Institute, Cairo University, Cairo 
      11796, Egypt.
FAU - Abdelkarim, Naglaa
AU  - Abdelkarim N
AD  - Department of Medicine, Hematology and Oncology, Medical College of Georgia, 
      Augusta University, Augusta, GA 30912, USA.
FAU - Gaudino, Mario
AU  - Gaudino M
AUID- ORCID: 0000-0003-4680-0815
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
FAU - Mohamed, Abdelrahman
AU  - Mohamed A
AD  - Surgical Oncology Department, National Cancer Institute, Cairo University, Cairo 
      11796, Egypt.
FAU - Girardi, Leonard
AU  - Girardi L
AD  - Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY 10065, 
      USA.
FAU - Zhang, Jun
AU  - Zhang J
AUID- ORCID: 0000-0001-7886-6187
AD  - Division of Medical Oncology, Department of Internal Medicine, University of 
      Kansas Medical Center, Kansas City, KS 66103, USA.
AD  - Department of Cancer Biology, University of Kansas Cancer Center, Kansas City, KS 
      66103, USA.
FAU - Mutti, Luciano
AU  - Mutti L
AUID- ORCID: 0000-0002-1578-2637
AD  - Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular 
      Medicine, College of Science and Technology, Temple University, Philadelphia, PA 
      19122, USA.
AD  - Department of Applied Clinical Sciences and Biotechnology, L'Aquila University, 
      67100 L'Aquila, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240313
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10969050
OTO - NOTNLM
OT  - adverse events
OT  - cancer
OT  - checkpoint inhibitors
OT  - hospital volume
OT  - immunotherapy
OT  - meta-analysis
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:45
MHDA- 2024/03/28 06:46
PMCR- 2024/03/13
CRDT- 2024/03/28 01:02
PHST- 2024/02/08 00:00 [received]
PHST- 2024/03/06 00:00 [revised]
PHST- 2024/03/11 00:00 [accepted]
PHST- 2024/03/28 06:46 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 01:02 [entrez]
PHST- 2024/03/13 00:00 [pmc-release]
AID - cancers16061136 [pii]
AID - cancers-16-01136 [pii]
AID - 10.3390/cancers16061136 [doi]
PST - epublish
SO  - Cancers (Basel). 2024 Mar 13;16(6):1136. doi: 10.3390/cancers16061136.