PMID- 38539671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 14
IP  - 3
DP  - 2024 Mar 15
TI  - Immersive Virtual Reality for Treatment of Unilateral Spatial Neglect via 
      Eye-Tracking Biofeedback: RCT Protocol and Usability Testing.
LID - 10.3390/brainsci14030283 [doi]
LID - 283
AB  - About one-third of stroke survivors present unilateral spatial neglect (USN) that 
      negatively impacts the rehabilitation outcome. We reported the study protocol and 
      usability results of an eye-tracking (ET) biofeedback immersive virtual reality 
      (iVR) protocol. Healthy controls and stroke patients with and without USN 
      underwent a single session of the three iVR tasks. The system usability scale 
      (SUS), adverse events (AEs), and ET data were collected and analyzed via 
      parametric analysis. Twelve healthy controls (six young adults and six older 
      adults) and seven patients with a diagnosis of single ischemic stroke (four 
      without USN and three with confirmed diagnosis of USN) completed the usability 
      investigation. SUS results showed good acceptability of the system for healthy 
      controls and stroke patients without USN. ET results showed a lower performance 
      for patients with USN concerning healthy controls and stroke patients without 
      USN, in particular in the exploration of the left visual field. The results 
      showed that the proposed iVR-ET biofeedback protocol is a safe and well-tolerated 
      technique in patients with USN. The real-time feedback can induce a performance 
      response supporting its investigation such as a treatment approach.
FAU - Martino Cinnera, Alex
AU  - Martino Cinnera A
AUID- ORCID: 0000-0001-7267-3253
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - Verna, Valeria
AU  - Verna V
AUID- ORCID: 0000-0003-1000-7655
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - Marucci, Matteo
AU  - Marucci M
AUID- ORCID: 0000-0001-6431-9238
AD  - Braintrends Limited, Applied Neuroscience, 00192 Rome, Italy.
AD  - Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Tavernese, Aurora
AU  - Tavernese A
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - Magnotti, Luisa
AU  - Magnotti L
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - Matano, Alessandro
AU  - Matano A
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - D'Acunto, Chiara
AU  - D'Acunto C
AD  - Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Paolucci, Stefano
AU  - Paolucci S
AUID- ORCID: 0000-0002-3105-1148
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - Morone, Giovanni
AU  - Morone G
AUID- ORCID: 0000-0003-3602-4197
AD  - Department of Life, Health and Environmental Sciences, University of L'Aquila, 
      67100 L'Aquila, Italy.
FAU - Betti, Viviana
AU  - Betti V
AUID- ORCID: 0000-0003-3429-2104
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
AD  - Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Tramontano, Marco
AU  - Tramontano M
AUID- ORCID: 0000-0001-6034-0638
AD  - Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater University 
      of Bologna, 40138 Bologna, Italy.
AD  - Unit of Occupational Medicine, IRCCS Azienda Ospedaliero-Universitaria di 
      Bologna, 40138 Bologna, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240315
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC10968842
OTO - NOTNLM
OT  - exergaming
OT  - eye movements
OT  - neglect
OT  - neurorehabilitation
OT  - stroke rehabilitation
OT  - visual deficits
COIS- Matteo Marucci is employed in Braintrends Limited, Applied Neuroscience. The 
      other authors declare no conflicts of interest.
EDAT- 2024/03/28 06:45
MHDA- 2024/03/28 06:46
PMCR- 2024/03/15
CRDT- 2024/03/28 01:03
PHST- 2024/02/26 00:00 [received]
PHST- 2024/03/12 00:00 [revised]
PHST- 2024/03/14 00:00 [accepted]
PHST- 2024/03/28 06:46 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 01:03 [entrez]
PHST- 2024/03/15 00:00 [pmc-release]
AID - brainsci14030283 [pii]
AID - brainsci-14-00283 [pii]
AID - 10.3390/brainsci14030283 [doi]
PST - epublish
SO  - Brain Sci. 2024 Mar 15;14(3):283. doi: 10.3390/brainsci14030283.