PMID- 38539969
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 14
IP  - 6
DP  - 2024 Mar 12
TI  - Dietary Hydroxytyrosol Supplementation on Growth Performance, Gut Morphometry, 
      and Oxidative and Inflammatory Status in LPS-Challenged Broilers.
LID - 10.3390/ani14060871 [doi]
LID - 871
AB  - This study assessed the effects of hydroxytyrosol (HT) on 8- to 20-day-old 
      broilers challenged with lipopolysaccharide (LPS); 180 Cobb500 male chicks were 
      randomly assigned to 3 treatment groups, each comprising 10 replicates with 6 
      birds per replicate. Treatments included a control diet (CON), CON with LPS 
      administration, and CON + LPS supplemented with 10 mg of HT/kg of feed. LPS was 
      administered intraperitoneally on days 14, 16, 18, and 20. Body weight (BW), body 
      weight gain (BWG), and the feed conversion ratio (FCR) were measured. On day 20, 
      ten birds per treatment were slaughtered for analysis. Bursa, spleen, and liver 
      were collected, and their respective relative weight was determined. The jejunum 
      was destined for morphological analyses of villus height (VH), crypt depth (CD), 
      and their ratio (VH:CD), and for mRNA expression of nuclear factor kappa B 
      (NF-kappaB), catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase 
      (SOD), and interleukins 10 (IL-10), 1 beta (IL-1beta), and 8 (IL-8). HT improved BW, 
      BWG, and FCR, and reduced crypt depth (CD) while increasing the VH:CD ratio in 
      the jejunum. Moreover, HT downregulated mRNA expression of CAT, GPx, IL-10, and 
      IL-1beta. In conclusion, HT enhances broiler growth performance, mitigates jejunal 
      mucosa damage from LPS, and modulates antioxidant and immune responses.
FAU - Dias, Kelly M M
AU  - Dias KMM
AUID- ORCID: 0000-0002-1757-3011
AD  - Department of Animal Science, Federal University of Vicosa, Vicosa 36570-900, 
      Minas Gerais, Brazil.
FAU - Oliveira, Carlos H
AU  - Oliveira CH
AD  - Department of Animal Science, Federal University of Vicosa, Vicosa 36570-900, 
      Minas Gerais, Brazil.
FAU - Calderano, Arele A
AU  - Calderano AA
AUID- ORCID: 0000-0002-2282-3580
AD  - Department of Animal Science, Federal University of Vicosa, Vicosa 36570-900, 
      Minas Gerais, Brazil.
FAU - Rostagno, Horacio S
AU  - Rostagno HS
AD  - Department of Animal Science, Federal University of Vicosa, Vicosa 36570-900, 
      Minas Gerais, Brazil.
FAU - Gomes, Kaique M
AU  - Gomes KM
AUID- ORCID: 0000-0002-2180-5209
AD  - Department of Animal Science, Federal University of Vicosa, Vicosa 36570-900, 
      Minas Gerais, Brazil.
FAU - O'Connor, Kevin E
AU  - O'Connor KE
AD  - Nova Mentis Limited, Nova UCD, Belfield Innovation Park, University College 
      Dublin, Belfield, D04 F438 Dublin, Ireland.
FAU - Davis, Reeta
AU  - Davis R
AD  - Nova Mentis Limited, Nova UCD, Belfield Innovation Park, University College 
      Dublin, Belfield, D04 F438 Dublin, Ireland.
FAU - Walsh, Meg
AU  - Walsh M
AUID- ORCID: 0000-0001-5186-2821
AD  - Nova Mentis Limited, Nova UCD, Belfield Innovation Park, University College 
      Dublin, Belfield, D04 F438 Dublin, Ireland.
FAU - Britton, James
AU  - Britton J
AD  - Nova Mentis Limited, Nova UCD, Belfield Innovation Park, University College 
      Dublin, Belfield, D04 F438 Dublin, Ireland.
FAU - Altieri, Enrico A
AU  - Altieri EA
AD  - Nova Mentis Limited, Nova UCD, Belfield Innovation Park, University College 
      Dublin, Belfield, D04 F438 Dublin, Ireland.
FAU - Albino, Luiz F T
AU  - Albino LFT
AD  - Department of Animal Science, Federal University of Vicosa, Vicosa 36570-900, 
      Minas Gerais, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20240312
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC10967364
OTO - NOTNLM
OT  - antioxidant
OT  - feed additives
OT  - gene expression
OT  - jejunum
OT  - lipopolysaccharide
COIS- Kevin O. Connor and Enrico Altieri are founders of Nova Mentis, Ltd. Reeta Davis, 
      Meg Walsh, and James Britton are employees of Nova Mentis, Ltd. Nova Mentis does 
      not have any patents related to the use of hydroxytyrosol in animals. Nova Mentis 
      produced hydroxytyrosol for this study, co-designed the animal feed experiments, 
      and analyzed the data generated in the study. The authors declare no conflict of 
      interest.
EDAT- 2024/03/28 06:46
MHDA- 2024/03/28 06:47
PMCR- 2024/03/12
CRDT- 2024/03/28 01:05
PHST- 2024/01/29 00:00 [received]
PHST- 2024/03/05 00:00 [revised]
PHST- 2024/03/11 00:00 [accepted]
PHST- 2024/03/28 06:47 [medline]
PHST- 2024/03/28 06:46 [pubmed]
PHST- 2024/03/28 01:05 [entrez]
PHST- 2024/03/12 00:00 [pmc-release]
AID - ani14060871 [pii]
AID - animals-14-00871 [pii]
AID - 10.3390/ani14060871 [doi]
PST - epublish
SO  - Animals (Basel). 2024 Mar 12;14(6):871. doi: 10.3390/ani14060871.