PMID- 38540230
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 12
IP  - 3
DP  - 2024 Mar 9
TI  - Associations of the CYP7A1 Gene Polymorphisms Located in the Promoter and 
      Enhancer Regions with the Risk of Acute Coronary Syndrome, Plasma Cholesterol, 
      and the Incidence of Diabetes.
LID - 10.3390/biomedicines12030617 [doi]
LID - 617
AB  - Cholesterol-7-alpha hydroxylase (CYP7A1) is a key enzyme in the synthesis of bile 
      salts, and its activity can contribute to determining cholesterol levels and, 
      consequently, the risk of developing coronary atherosclerotic disease. We 
      evaluated whether seven (rs3808607 G/T, rs9297994 G/A, rs10504255 A/G, rs8192870 
      G/T, rs2081687 C/T, rs1457043 C/T, and rs10107182 C/T) polymorphisms located in 
      the promoter and enhancer regions of the CYP7A1 gene, which have not been 
      sufficiently explored, are candidates of risk markers of acute coronary syndrome 
      (ACS) in the Mexican population. These polymorphisms were determined in a group 
      of 1317 patients with ACS and 1046 control subjects. The results showed that, 
      under different inheritance models, the alleles rs9297994 G, rs10504255 G, 
      rs8192870 T, rs2081687 T, and rs10107182 C were significantly associated with an 
      increased risk of ACS (pC < 0.05). In addition, the incidence of dyslipidemia 
      among patients with ACS, notably high total cholesterol and LDL-cholesterol, and 
      low HDL-cholesterol plasma levels, were more frequent in carriers of the same 
      five risk alleles associated with ACS (p < 0.05). There was also an unexpected 
      increased incidence of type 2 diabetes mellitus (T2DM) in patients with ACS who 
      are homozygous for the rs2081687 T, rs9297944 G, rs10504255 G, and rs10107182 C 
      alleles of the CYP7A1 gene, suggesting that such gene variants enhance the 
      development of coronary complications in patients with diabetes (p < 0.05). In 
      summary, our study demonstrated that five polymorphisms situated in the promoter 
      and enhancer regions of the CYP7A1 gene are associated with the risk of ACS and 
      higher incidences of dyslipidemia and T2DM in Mexican patients with ACS.
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
AUID- ORCID: 0000-0001-7916-5163
AD  - Direccion de Investigacion, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Juan Badiano No. 1 Tlalpan, Mexico City 14080, Mexico.
FAU - Perez-Mendez, Oscar
AU  - Perez-Mendez O
AUID- ORCID: 0000-0002-6977-1829
AD  - Departamento de Biologia Molecular, Instituto Nacional de Cardiologia Ignacio 
      Chavez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.
FAU - Posadas-Sanchez, Rosalinda
AU  - Posadas-Sanchez R
AUID- ORCID: 0000-0001-8467-3488
AD  - Departamento de Endocrinologia, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Juan Badiano No. 1 Tlalpan, Mexico City 14080, Mexico.
FAU - Gonzalez-Pacheco, Hector
AU  - Gonzalez-Pacheco H
AUID- ORCID: 0000-0002-4370-9963
AD  - Unidad Coronaria, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 
      No. 1 Tlalpan, Mexico City 14080, Mexico.
FAU - Luna-Luna, Maria
AU  - Luna-Luna M
AUID- ORCID: 0000-0003-3914-9366
AD  - Departamento de Biologia Molecular, Instituto Nacional de Cardiologia Ignacio 
      Chavez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.
FAU - Escobedo, Galileo
AU  - Escobedo G
AUID- ORCID: 0000-0002-9224-7400
AD  - Direccion de Investigacion y Laboratorio de Inmunometabolismo, Hospital General 
      de Mexico "Dr. Eduardo Liceaga", Dr. Balmis No. 148, Cuauhtemoc, Mexico City 
      06720, Mexico.
FAU - Fragoso, Jose Manuel
AU  - Fragoso JM
AUID- ORCID: 0000-0003-3137-7815
AD  - Departamento de Biologia Molecular, Instituto Nacional de Cardiologia Ignacio 
      Chavez, Juan Badiano No. 1, Tlalpan, Mexico City 14080, Mexico.
LA  - eng
GR  - 22-1288/Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico/
PT  - Journal Article
DEP - 20240309
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10968401
OTO - NOTNLM
OT  - acute coronary syndrome
OT  - cholesterol 7 alpha-hydroxylase
OT  - genetics
OT  - susceptibility
COIS- The authors declare no conflict of interest.
EDAT- 2024/03/28 06:44
MHDA- 2024/03/28 06:45
PMCR- 2024/03/09
CRDT- 2024/03/28 01:06
PHST- 2024/02/20 00:00 [received]
PHST- 2024/03/03 00:00 [revised]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/28 06:45 [medline]
PHST- 2024/03/28 06:44 [pubmed]
PHST- 2024/03/28 01:06 [entrez]
PHST- 2024/03/09 00:00 [pmc-release]
AID - biomedicines12030617 [pii]
AID - biomedicines-12-00617 [pii]
AID - 10.3390/biomedicines12030617 [doi]
PST - epublish
SO  - Biomedicines. 2024 Mar 9;12(3):617. doi: 10.3390/biomedicines12030617.