PMID- 38541107
OWN - NLM
STAT- MEDLINE
DCOM- 20240329
LR  - 20240330
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 60
IP  - 3
DP  - 2024 Feb 24
TI  - Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Index at Diagnosis Is 
      Associated with All-Cause Mortality during Follow-Up in Patients with 
      Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
LID - 10.3390/medicina60030381 [doi]
LID - 381
AB  - Background and Objectives: The purpose of this study was to investigate whether a 
      new index related to chronic liver disease, the alcoholic liver 
      disease/nonalcoholic fatty liver disease index (ANI) at diagnosis, is associated 
      with all-cause mortality during follow-up in patients with antineutrophil 
      cytoplasmic antibody-associated vasculitis (AAV). Materials and Methods: In this 
      study, we included 270 patients with AAV. ANI was calculated using the following 
      equation: ANI = -58.5 + 0.637 (adjusted mean corpuscular volume) + 3.91 (adjusted 
      aspartate transaminase/alanine transaminase) - 0.406 (body mass index) + 6.35 (if 
      male sex). All-cause mortality was defined as death from any cause during 
      follow-up. Results: The median age of the 270 patients with AAV was 61.0 years 
      (34.4% male and 66.6% female). The median ANI was significantly higher in 
      deceased patients than in surviving patients. In the receiver operating 
      characteristic curve analysis, ANI at diagnosis exhibited a statistically 
      significant area under the curve for all-cause mortality during follow-up, and 
      its cut-off was determined to be -0.59. Patients with ANI at diagnosis >/= -0.59 
      exhibited a significantly higher risk for all-cause mortality and a significantly 
      lower cumulative patient survival rate than those without. In the multivariable 
      Cox analysis, ANI at diagnosis >/= -0.59, together with age at diagnosis, was 
      independently associated with all-cause mortality. Conclusions: This study is the 
      first to demonstrate the predictive potential of ANI at diagnosis for all-cause 
      mortality during follow-up in AAV patients without significant chronic liver 
      diseases.
FAU - Cho, Minsuk
AU  - Cho M
AD  - Department of Medicine, Yonsei University College of Medicine, Seoul 03722, 
      Republic of Korea.
FAU - Rah, Woongchan
AU  - Rah W
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Republic of Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul 03722, Republic of Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul 03722, Republic of Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul 03722, Republic of Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul 03722, Republic of Korea.
LA  - eng
GR  - NCR 2019-6/CELLTRION PHARM, Inc. Chungcheongbuk-do, Republic of Korea/
GR  - N/A/Chong Kun Dang Pharmaceutical Corp, Seoul, Republic of Korea/
PT  - Journal Article
DEP - 20240224
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Middle Aged
MH  - *Non-alcoholic Fatty Liver Disease/complications
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Follow-Up Studies
MH  - *Liver Diseases, Alcoholic/diagnosis/complications
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications
MH  - Retrospective Studies
PMC - PMC10972080
OTO - NOTNLM
OT  - alcoholic liver disease/nonalcoholic fatty liver disease index
OT  - antineutrophil cytoplasmic antibody
OT  - estimate
OT  - mortality
OT  - vasculitis
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:45
MHDA- 2024/03/29 06:46
PMCR- 2024/02/24
CRDT- 2024/03/28 01:11
PHST- 2024/01/09 00:00 [received]
PHST- 2024/02/21 00:00 [revised]
PHST- 2024/02/22 00:00 [accepted]
PHST- 2024/03/29 06:46 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 01:11 [entrez]
PHST- 2024/02/24 00:00 [pmc-release]
AID - medicina60030381 [pii]
AID - medicina-60-00381 [pii]
AID - 10.3390/medicina60030381 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2024 Feb 24;60(3):381. doi: 10.3390/medicina60030381.