PMID- 38541659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 14
IP  - 3
DP  - 2024 Mar 2
TI  - An Exploratory Bioinformatic Investigation of Cats' Susceptibility to 
      Coronavirus-Deriving Epitopes.
LID - 10.3390/life14030334 [doi]
LID - 334
AB  - Coronaviruses are highly transmissible and pathogenic viruses for humans and 
      animals. The vast quantity of information collected about SARS-CoV-2 during the 
      pandemic helped to unveil details of the mechanisms behind the infection, which 
      are still largely elusive. Recent research demonstrated that different class I/II 
      human leukocyte antigen (HLA) alleles might define an individual susceptibility 
      to SARS-CoV-2 spreading, contributing to the differences in the distribution of 
      the infection through different populations; additional studies suggested that 
      the homolog of the HLA in cats, the feline leukocyte antigen (FLA), plays a 
      pivotal role in the transmission of viruses. With these premises, this study 
      aimed to exploit a bioinformatic approach for the prediction of the 
      transmissibility potential of two distinct feline coronaviruses (FCoVs) in 
      domestic cats (feline enteric coronavirus (FeCV) and feline infectious 
      peritonitis virus (FIPV)) using SARS-CoV-2 as the reference model. We performed 
      an epitope mapping of nonapeptides deriving from SARS-CoV-2, FeCV, and FIPV 
      glycoproteins and predicted their affinities for different alleles included in 
      the three main loci in class I FLAs (E, H, and K). The predicted complexes with 
      the most promising affinities were then subjected to molecular docking and 
      molecular dynamics simulations to provide insights into the stability and binding 
      energies in the cleft. Results showed the FLA proteins encoded by alleles in the 
      FLA-I H (H*00501 and H*00401) and E (E*01001 and E*00701) loci are largely 
      responsive to several epitopes deriving from replicase and spike proteins of the 
      analyzed coronaviruses. The analysis of the most affine epitope sequences 
      resulting from the prediction can stimulate the development of anti-FCoV 
      immunomodulatory strategies based on peptide drugs.
FAU - Buonocore, Michela
AU  - Buonocore M
AD  - Department of Veterinary Medicine and Animal Production, University of Naples 
      Federico II, Via Federico Delpino, 1, 80137 Napoli, Italy.
AD  - Department of Chemical Sciences, Research Centre on Bioactive Peptides (CIRPeB), 
      University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, 
      Via Cintia, 80126 Naples, Italy.
FAU - De Biase, Davide
AU  - De Biase D
AUID- ORCID: 0000-0002-8118-9807
AD  - Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 
      Fisciano, Italy.
FAU - Sorrentino, Domenico
AU  - Sorrentino D
AD  - Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 
      Fisciano, Italy.
FAU - Giordano, Antonio
AU  - Giordano A
AD  - Sbarro Institute for Cancer Research and Molecular Medicine, Center for 
      Biotechnology, College of Science and Technology, Temple University, 
      Philadelphia, PA 19122, USA.
AD  - Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
FAU - Paciello, Orlando
AU  - Paciello O
AD  - Department of Veterinary Medicine and Animal Production, University of Naples 
      Federico II, Via Federico Delpino, 1, 80137 Napoli, Italy.
FAU - D'Ursi, Anna Maria
AU  - D'Ursi AM
AD  - Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 
      Fisciano, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240302
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC10971392
OTO - NOTNLM
OT  - MHC
OT  - coronavirus
OT  - immunity system
OT  - peptides
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:45
MHDA- 2024/03/28 06:46
PMCR- 2024/03/02
CRDT- 2024/03/28 01:14
PHST- 2024/01/26 00:00 [received]
PHST- 2024/02/26 00:00 [revised]
PHST- 2024/02/27 00:00 [accepted]
PHST- 2024/03/28 06:46 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 01:14 [entrez]
PHST- 2024/03/02 00:00 [pmc-release]
AID - life14030334 [pii]
AID - life-14-00334 [pii]
AID - 10.3390/life14030334 [doi]
PST - epublish
SO  - Life (Basel). 2024 Mar 2;14(3):334. doi: 10.3390/life14030334.