PMID- 38541924
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 13
IP  - 6
DP  - 2024 Mar 15
TI  - Comparison of Long-Term Postoperative Outcomes of the Subtypes of Chronic 
      Rhinosinusitis with Nasal Polyps.
LID - 10.3390/jcm13061699 [doi]
LID - 1699
AB  - (1) Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic 
      inflammatory condition that significantly impacts the health-related quality of 
      life (HRQOL) of patients. This study aims to investigate the disparities in 
      preoperative examination findings, postoperative HRQOL, and disease control 
      status based on CRSwNP subtypes. (2) Methods: A retrospective analysis was 
      conducted on 202 patients who underwent endoscopic sinus surgery for CRSwNP. The 
      study assessed clinical characteristics, blood eosinophil and immunoglobulin E 
      (IgE) levels, modified Lund-Kennedy and Lund-Mackay scores, and Japanese 
      Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) 
      scores. HRQOL was evaluated using the Sino-nasal Outcome Test (SNOT-22) scores, 
      and disease control status was assessed based on the European Position Paper on 
      Rhinosinusitis and Nasal Polyps 2020 guidelines. (3) Results: Of the 202 
      patients, Eosinophilic CRSwNP patients exhibited significantly higher 
      preoperative peripheral blood eosinophil ratios and IgE levels, and JESREC scores 
      (p < 0.05). Two years postoperatively, patients in the non-eosinophilic group 
      showed significantly improved SNOT-22 scores compared to preoperative scores (p = 
      0.007). Notably, the proportion of patients with uncontrolled disease was 
      significantly higher in the eosinophilic group (p = 0.035). Logistic regression 
      analyses identified preoperative SNOT-22 scores and eosinophilic CRSwNP subtype 
      as influential factors on disease control status (p < 0.05). (4) Conclusions: 
      Patients with more severe preoperative symptoms and eosinophilic CRSwNP 
      demonstrated poorer long-term treatment outcomes.
FAU - Lee, Sang-Min
AU  - Lee SM
AD  - Department of Otorhinolaryngology, College of Medicine, Dankook University, 119 
      Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam-do, Republic of Korea.
FAU - Yoo, Shin-Hyuk
AU  - Yoo SH
AUID- ORCID: 0000-0002-5083-8720
AD  - Department of Otorhinolaryngology, College of Medicine, Dankook University, 119 
      Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam-do, Republic of Korea.
FAU - Mo, Ji-Hun
AU  - Mo JH
AD  - Department of Otorhinolaryngology, College of Medicine, Dankook University, 119 
      Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam-do, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20240315
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10971608
OTO - NOTNLM
OT  - chronic rhinosinusitis
OT  - disease control status
OT  - health-related quality of life
OT  - nasal polyps
OT  - subtype
OT  - surgery
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:45
MHDA- 2024/03/28 06:46
PMCR- 2024/03/15
CRDT- 2024/03/28 01:16
PHST- 2024/01/30 00:00 [received]
PHST- 2024/03/08 00:00 [revised]
PHST- 2024/03/14 00:00 [accepted]
PHST- 2024/03/28 06:46 [medline]
PHST- 2024/03/28 06:45 [pubmed]
PHST- 2024/03/28 01:16 [entrez]
PHST- 2024/03/15 00:00 [pmc-release]
AID - jcm13061699 [pii]
AID - jcm-13-01699 [pii]
AID - 10.3390/jcm13061699 [doi]
PST - epublish
SO  - J Clin Med. 2024 Mar 15;13(6):1699. doi: 10.3390/jcm13061699.