PMID- 38543603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 12
IP  - 3
DP  - 2024 Mar 11
TI  - Research Progress on the NSP10 Protein of Porcine Reproductive and Respiratory 
      Syndrome Virus.
LID - 10.3390/microorganisms12030553 [doi]
LID - 553
AB  - Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and 
      pathogenic infectious disease caused by the porcine reproductive and respiratory 
      syndrome virus (PRRSV). It manifests as reproductive disorders in sows and 
      respiratory disorders in piglets. PRRSV infects swine herds with symptoms such as 
      abortions, stillbirths, and mummified fetuses in gestating sows. Piglets mainly 
      experience abdominal respiration and respiratory symptoms. To date, the 
      prevention of PRRS relies primarily on vaccination and the implementation of 
      various preventive and control measures. Swine deaths caused by PRRS have 
      resulted in significant economic losses to the pig industry worldwide. 
      Non-structural protein 10 (NSP10) has helicase and adenosine triphosphatase 
      (ATPase) activities that unwind DNA and RNA and play important roles in viral 
      replication and transcription. Hence, it can be potentially used to develop novel 
      reagents for the detection of PPRSV. This article reviews genetic variations, 
      interaction with viral and host proteins, effects on PRRSV replication, 
      immunomodulation, apoptosis, and viral virulence of NSP10, with the aim of 
      providing a theoretical basis for the prevention and control of PRRS and drug 
      development in the future.
FAU - Li, Gan
AU  - Li G
AD  - School of Life Science and Engineering, Foshan University, Foshan 528225, China.
FAU - Zheng, Yajie
AU  - Zheng Y
AD  - School of Life Science and Engineering, Foshan University, Foshan 528225, China.
FAU - Luo, Qin
AU  - Luo Q
AD  - School of Life Science and Engineering, Foshan University, Foshan 528225, China.
FAU - Liang, Yaohua
AU  - Liang Y
AUID- ORCID: 0000-0002-6214-9340
AD  - Department of Agricultural and Biosystems Engineering, South Dakota State 
      University, Brookings, SD 57007, USA.
FAU - Zhang, Hang
AU  - Zhang H
AD  - School of Life Science and Engineering, Foshan University, Foshan 528225, China.
FAU - Sha, Huiyang
AU  - Sha H
AD  - School of Life Science and Engineering, Foshan University, Foshan 528225, China.
FAU - Wang, Ruining
AU  - Wang R
AD  - College of Veterinary Medicine, Henan University of Animal Husbandry and Economy, 
      Zhengzhou 450046, China.
FAU - Kong, Weili
AU  - Kong W
AUID- ORCID: 0000-0002-9104-7730
AD  - Gladstone Institutes of Virology and Immunology, University of California, San 
      Francisco, CA 94158, USA.
FAU - Zhao, Mengmeng
AU  - Zhao M
AUID- ORCID: 0000-0003-4143-3606
AD  - School of Life Science and Engineering, Foshan University, Foshan 528225, China.
LA  - eng
GR  - 2023KTSCX128/the characteristic innovation project of Guangdong Provincial 
      Department of Education/
GR  - 31902279/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20240311
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC10975305
OTO - NOTNLM
OT  - NSP10
OT  - PRRSV
OT  - apoptosis
OT  - genetic evolution
OT  - helicase
OT  - viral virulence
COIS- The authors declare no conflicts of interest.
EDAT- 2024/03/28 06:46
MHDA- 2024/03/28 06:47
PMCR- 2024/03/11
CRDT- 2024/03/28 01:26
PHST- 2024/01/16 00:00 [received]
PHST- 2024/03/03 00:00 [revised]
PHST- 2024/03/08 00:00 [accepted]
PHST- 2024/03/28 06:47 [medline]
PHST- 2024/03/28 06:46 [pubmed]
PHST- 2024/03/28 01:26 [entrez]
PHST- 2024/03/11 00:00 [pmc-release]
AID - microorganisms12030553 [pii]
AID - microorganisms-12-00553 [pii]
AID - 10.3390/microorganisms12030553 [doi]
PST - epublish
SO  - Microorganisms. 2024 Mar 11;12(3):553. doi: 10.3390/microorganisms12030553.