PMID- 38544461
OWN - NLM
STAT- Publisher
LR  - 20240328
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
DP  - 2024 Mar 28
TI  - The use of splenic embolization in immune thrombocytopenia: A systematic review 
      and meta-analysis.
LID - 10.1111/bjh.19418 [doi]
AB  - The effectiveness of splenic embolization (SE) in treating refractory immune 
      thrombocytopenia (ITP) remains uncertain. A systematic literature review was 
      undertaken to assess the effectiveness and safety of SE in treating both 
      paediatric and adult patients with ITP. We conducted an extensive search 
      employing predefined criteria. We extracted platelet counts at baseline and at 
      multiple intervals following SE, along with details of the proportion of 
      embolized spleen parenchyma and the proportion of patients exhibiting complete or 
      partial platelet count responses. We identified nine eligible reports for the 
      analysis of effectiveness (228 patients) and 15 reports for the safety analysis 
      (151 patients). Pooled estimates of complete response (platelet count 
      >100 x 10(9)/L) and overall response (platelet count >30 x 10(9)/L) were 50.1% 
      (95% CI: 38-62.3) and 74.4% (95% CI: 64.9-83.9) respectively. Most studies 
      applied an embolization of at least 60% of the spleen parenchyma. Nearly all the 
      patients suffered from mild adverse events (AEs), 1.3% suffered from serious AEs 
      and one patient died (0.7%). In conclusion, SE resulted in an overall response 
      rate in 74.4% of patients with ITP. However, this finding derives from 
      uncontrolled studies of low to moderate quality.
CI  - (c) 2024 British Society for Haematology and John Wiley & Sons Ltd.
FAU - Egbaria, A
AU  - Egbaria A
AD  - Department of Medicine D, Emek Medical Center, Clalit Health Services, Afula, 
      Israel.
FAU - Touma, E
AU  - Touma E
AD  - Department of Medicine D, Emek Medical Center, Clalit Health Services, Afula, 
      Israel.
FAU - Cohen-Abadi, M
AU  - Cohen-Abadi M
AD  - Research Center, Emek Medical Center, Clalit Health Services, Afula, Israel.
FAU - Bisharat, N
AU  - Bisharat N
AUID- ORCID: 0000-0002-2313-5683
AD  - Department of Medicine D, Emek Medical Center, Clalit Health Services, Afula, 
      Israel.
AD  - Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 
      Israel.
LA  - eng
PT  - Journal Article
DEP - 20240328
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
OTO - NOTNLM
OT  - immune thrombocytopenia
OT  - platelet count response
OT  - splenic embolization
EDAT- 2024/03/28 06:46
MHDA- 2024/03/28 06:46
CRDT- 2024/03/28 03:33
PHST- 2024/03/10 00:00 [revised]
PHST- 2024/01/14 00:00 [received]
PHST- 2024/03/12 00:00 [accepted]
PHST- 2024/03/28 06:46 [medline]
PHST- 2024/03/28 06:46 [pubmed]
PHST- 2024/03/28 03:33 [entrez]
AID - 10.1111/bjh.19418 [doi]
PST - aheadofprint
SO  - Br J Haematol. 2024 Mar 28. doi: 10.1111/bjh.19418.