PMID- 38545188
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 6
DP  - 2024 Mar 30
TI  - Susceptibility of TSPAN5 polymorphisms to Kawasaki disease and immunoglobulin 
      therapy resistance in southern Chinese children.
PG  - e27699
LID - 10.1016/j.heliyon.2024.e27699 [doi]
LID - e27699
AB  - Kawasaki disease (KD) is a condition characterized by acute multi-system 
      vasculitis and high fever in infants and children. Intravenous immunoglobulin 
      (IVIG) is the established therapeutic approach of KD,foralleviating inflammation 
      and mitigate the risk of arterial wall dilation and the development of coronary 
      artery aneurysms (CAA). But almost 20% of the patients developed resistance to 
      IVIG and displayed persistent fever after standard primary treatment. TSPAN5, 
      belonging to the Tetraspanin family, has been demonstrated to modulate innate 
      immunity in a range of human diseases. It accomplishes this by engaging with 
      integrins and actively participating in the process of infection recognition. 
      However, its relevance to susceptibility and IVIG therapy response of KD was 
      unexposed. In the present study, our Integrative analysis of KD transcriptomic 
      data and GTEx data revealed that the eQTL rs12504972 might modify the 
      downregulation of TSPAN5 in KD patients. Moreover, our findings suggest a 
      potential association between TSPAN5/rs12504972 and an elevated susceptibility as 
      well as IVIG resistance among patients with Kawasaki disease in southern China. 
      The results provided a new insight that TSPAN5 triggered KD susceptibility and 
      resistance of IVIG therapy on the genomic level.
CI  - (c) 2024 The Authors.
FAU - Chen, Kaining
AU  - Chen K
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Luo, Xilian
AU  - Luo X
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Zhou, Huazhong
AU  - Zhou H
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Fu, Lanyan
AU  - Fu L
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Lu, Zhaojin
AU  - Lu Z
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Wang, Chenlu
AU  - Wang C
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Lin, Yueling
AU  - Lin Y
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Yu, Hongyan
AU  - Yu H
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Xu, Yufen
AU  - Xu Y
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Pi, Lei
AU  - Pi L
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Che, Di
AU  - Che D
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
FAU - Wang, Zhouping
AU  - Wang Z
AD  - Department of Cardiology, Guangzhou Women and Children's Medical Center, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Gu, Xiaoqiong
AU  - Gu X
AD  - Department of Clinical Biological Resource Bank, Guangzhou Institute of 
      Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth 
      Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical 
      University, Guangzhou, 510620, China.
LA  - eng
PT  - Journal Article
DEP - 20240312
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10966590
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/03/28 06:46
MHDA- 2024/03/28 06:47
PMCR- 2024/03/12
CRDT- 2024/03/28 04:05
PHST- 2023/08/05 00:00 [received]
PHST- 2023/12/19 00:00 [revised]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/28 06:47 [medline]
PHST- 2024/03/28 06:46 [pubmed]
PHST- 2024/03/28 04:05 [entrez]
PHST- 2024/03/12 00:00 [pmc-release]
AID - S2405-8440(24)03730-7 [pii]
AID - e27699 [pii]
AID - 10.1016/j.heliyon.2024.e27699 [doi]
PST - epublish
SO  - Heliyon. 2024 Mar 12;10(6):e27699. doi: 10.1016/j.heliyon.2024.e27699. 
      eCollection 2024 Mar 30.