PMID- 38545661
OWN - NLM
STAT- Publisher
LR  - 20240328
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
DP  - 2024 Mar 28
TI  - Cyclooxygenase products contribute to the exaggerated exercise pressor reflex 
      evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats.
LID - 10.1152/japplphysiol.00879.2023 [doi]
AB  - Cyclooxygenase (COX) products of arachidonic acid metabolism, specifically 
      prostaglandins, play a role in evoking and transmitting the exercise pressor 
      reflex in health and disease. Individuals with type 2 diabetes mellitus (T2DM) 
      have an exaggerated exercise pressor reflex; however, the mechanisms for this 
      exaggerated reflex are not fully understood. We aimed to determine the role 
      played by COX products in the exaggerated exercise pressor reflex in T2DM rats. 
      The exercise pressor reflex was evoked by static muscle contraction in 
      unanesthetized, decerebrate, male, adult UCD-T2DM (n=8) and healthy 
      Sprague-Dawley (n=8) rats. Changes (∆) in peak mean arterial pressure (MAP) and 
      heart rate (HR) during muscle contraction were compared before and after 
      intra-arterial injection of indomethacin (1 mg/kg) into the contracting hindlimb. 
      Data are presented as mean +/- SD. Inhibition of COX activity attenuated the 
      exaggerated peak MAP (Before: ∆32 +/- 13 mmHg, After: ∆18 +/- 8 mmHg; P=0.004) and 
      blood pressor index (BPi) (Before: ∆683 +/- 324 mmHg.s, After: ∆361 +/- 222 mmHg.s; 
      P=0.006), but not HR (Before: ∆23 +/- 8 bpm, After ∆19 +/- 10 bpm; P=0.452) responses 
      to muscle contraction in T2DM rats. In healthy rats, COX activity inhibition did 
      not affect MAP, HR or BPi responses to muscle contraction. Inhibition of COX 
      activity significantly reduced local production of prostaglandin E(2) in T2DM and 
      healthy rats. We conclude that peripheral inhibition of COX activity attenuates 
      the pressor response to muscle contraction in T2DM rats, suggesting that COX 
      products partially contribute to the exaggerated exercise pressor reflex in those 
      with T2DM.
FAU - Samora, Milena
AU  - Samora M
AD  - Department of Kinesiology & Health Education, The University of Texas at Austin, 
      Austin, TX, United States. ROR: https://ror.org/00hj54h04
FAU - Huo, Yu
AU  - Huo Y
AD  - Department of Kinesiology & Health Education, The University of Texas at Austin, 
      Austin, TX, United States. ROR: https://ror.org/00hj54h04
FAU - Stanhope, Kimber L
AU  - Stanhope KL
AD  - Department of Molecular Biosciences, School of Veterinary Medicine, University of 
      California, Davis, Davis, California, United States. ROR: 
      https://ror.org/05rrcem69
FAU - Havel, Peter J
AU  - Havel PJ
AD  - Department of Veterinary Medicine and Epidemiology, University of California, 
      Davis, Davis,, California, United States. ROR: https://ror.org/05rrcem69
FAU - Kaufman, Marc P
AU  - Kaufman MP
AD  - Heart and Vascular Institute, Penn State Milton S. Hershey Medical Center, 
      Hershey, PA, United States. ROR: https://ror.org/01h22ap11
FAU - Harrison, Michelle L
AU  - Harrison ML
AD  - Department of Kinesiology & Health Education, The University of Texas at Austin, 
      Austin, TX, United States. ROR: https://ror.org/00hj54h04
FAU - Stone, Audrey J
AU  - Stone AJ
AD  - Department of Kinesiology and Health Education, The University of Texas at 
      Austin, Austin, TX, United States. ROR: https://ror.org/00hj54h04
LA  - eng
GR  - HL-144723/HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)/
PT  - Journal Article
DEP - 20240328
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
OTO - NOTNLM
OT  - Autonomic control of circulation
OT  - Blood pressure
OT  - Cyclooxygenase activity
OT  - Indomethacin
OT  - Type III/IV afferent fibers
EDAT- 2024/03/28 06:44
MHDA- 2024/03/28 06:44
CRDT- 2024/03/28 04:16
PHST- 2024/03/28 06:44 [medline]
PHST- 2024/03/28 06:44 [pubmed]
PHST- 2024/03/28 04:16 [entrez]
AID - 10.1152/japplphysiol.00879.2023 [doi]
PST - aheadofprint
SO  - J Appl Physiol (1985). 2024 Mar 28. doi: 10.1152/japplphysiol.00879.2023.