PMID- 3857869 OWN - NLM STAT- MEDLINE DCOM- 19850612 LR - 20191030 IS - 8755-8920 (Print) IS - 8755-8920 (Linking) VI - 7 IP - 3 DP - 1985 Mar TI - Mating is random. PG - 124-6 AB - Human leukocyte antigen (HLA) typing was undertaken in 151 unrelated blood donors and in 35 normal couples having at least two living children. We compared observed and expected sharing of HLA antigens at four loci in normal couples. We also compared the observed sharing in couples with the expected sharing in unrelated blood donors if taken two by two and with the sharing observed after 1000 "synthetic matings" of normal couples. No statistically significant difference in HLA sharing appeared between these groups. Furthermore no differences were observed in the probabilities of sharing individual HLA antigens among the different groups. We thus conclude that the observed HLA sharing in normal couples is governed by chance alone and that mating is random in our population. FAU - Bischof, P AU - Bischof P FAU - Jeannet, M AU - Jeannet M FAU - Bourrit, B AU - Bourrit B FAU - Vuagnat, P AU - Vuagnat P FAU - Herrmann, W L AU - Herrmann WL FAU - Sizonenko, P C AU - Sizonenko PC LA - eng PT - Journal Article PL - United States TA - Am J Reprod Immunol Microbiol JT - American journal of reproductive immunology and microbiology : AJRIM JID - 8501543 RN - 0 (HLA Antigens) RN - 0 (Histocompatibility Antigens Class II) SB - IM MH - Female MH - Fertilization MH - HLA Antigens/*genetics MH - Histocompatibility Antigens Class II/*genetics MH - Humans MH - *Major Histocompatibility Complex MH - Male MH - Polymorphism, Genetic MH - Probability EDAT- 1985/03/01 00:00 MHDA- 1985/03/01 00:01 CRDT- 1985/03/01 00:00 PHST- 1985/03/01 00:00 [pubmed] PHST- 1985/03/01 00:01 [medline] PHST- 1985/03/01 00:00 [entrez] AID - 10.1111/j.1600-0897.1985.tb00270.x [doi] PST - ppublish SO - Am J Reprod Immunol Microbiol. 1985 Mar;7(3):124-6. doi: 10.1111/j.1600-0897.1985.tb00270.x.