PMID- 3859251 OWN - NLM STAT- MEDLINE DCOM- 19850711 LR - 20210826 IS - 0385-0684 (Print) IS - 0385-0684 (Linking) VI - 12 IP - 6 DP - 1985 Jun TI - [Combination effects of CDDP, ACR and HCFU on progressive urothelial tumors]. PG - 1318-22 AB - Nine patients with progressive urothelial tumors treated with combination chemotherapy were evaluated. The median age of the patients was fifty-four; 6 men and 3 women; 7 of the tumors were of the renal pelvis and/or ureter and at stage C or D at the time of initial chemotherapy. Another of the tumors was triple cancer (bladder, prostate, sigmoid) and the remaining case was of bladder cancer. The stage of the two bladders cancers was T4. All patients were treated with CDDP (cis-platinum), ACR (aclarubicin hydrochloride) and HCFU (carmoful) and given from one to 3 courses repeated at three-week intervals (mean 2.3 courses). Seven patients were evaluable while two had no evaluable lesions. The response with this chemotherapy was 2 cases of PR (28.5%), 4 cases of NC and one case of PD. No severe toxicities such as nephrotoxicity or cardiotoxicity, were revealed with this combination chemotherapy. FAU - Ueda, K AU - Ueda K FAU - Jinno, H AU - Jinno H FAU - Watanabe, H AU - Watanabe H FAU - Ohtaguro, K AU - Ohtaguro K LA - jpn PT - Journal Article PL - Japan TA - Gan To Kagaku Ryoho JT - Gan to kagaku ryoho. Cancer & chemotherapy JID - 7810034 RN - 0 (Naphthacenes) RN - 74KXF8I502 (Aclarubicin) RN - HA82M3RAB2 (carmofur) RN - Q20Q21Q62J (Cisplatin) RN - U3P01618RT (Fluorouracil) SB - IM MH - Aclarubicin MH - Adult MH - Aged MH - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use MH - Cisplatin/administration & dosage MH - Drug Administration Schedule MH - Female MH - Fluorouracil/administration & dosage/analogs & derivatives MH - Humans MH - Kidney Neoplasms/drug therapy MH - Kidney Pelvis MH - Male MH - Middle Aged MH - Naphthacenes/administration & dosage MH - Ureteral Neoplasms/drug therapy MH - Urinary Bladder Neoplasms/drug therapy MH - Urologic Neoplasms/*drug therapy EDAT- 1985/06/01 00:00 MHDA- 1985/06/01 00:01 CRDT- 1985/06/01 00:00 PHST- 1985/06/01 00:00 [pubmed] PHST- 1985/06/01 00:01 [medline] PHST- 1985/06/01 00:00 [entrez] PST - ppublish SO - Gan To Kagaku Ryoho. 1985 Jun;12(6):1318-22.