PMID- 3860403
OWN - NLM
STAT- MEDLINE
DCOM- 19850916
LR  - 20170920
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 44
IP  - 2
DP  - 1985 Aug
TI  - Adverse effects of human leukocyte antigen-DR sharing on fertility: a cohort 
      study in a human isolate.
PG  - 227-32
AB  - To elucidate further the reproductive effects of human leukocyte antigen (HLA) 
      sharing among spouses, we have been investigating prospectively the relationship 
      between HLA-A, -B, and -DR sharing and reproductive outcome in the Hutterites, a 
      religious isolate that proscribes contraception. For the first time the 
      reproductive effects of HLA-DR sharing in a fertile population is reported in 
      this article. Median intervals from marriage to first through fifth births were 
      longer among couples who shared more than one HLA-A, -B, or -DR antigen. Longer 
      intervals were associated with increased spontaneous abortion rates among couples 
      who shared HLA-DR antigens (27%), compared with couples who shared only HLA-A or 
      -B antigens (9%) and couples who shared no antigens (12%). Median completed 
      family sizes were 5.0, 8.5, and 8.0 among the groups, respectively. However, some 
      couples who shared HLA-DR antigens experienced no spontaneous abortions, despite 
      ten or more pregnancies. Therefore, although HLA-DR compatibility, per se, is not 
      deleterious, our data suggest a potentially important role for undefined 
      HLA-linked genes in normal pregnancy.
FAU - Ober, C L
AU  - Ober CL
FAU - Hauck, W W
AU  - Hauck WW
FAU - Kostyu, D D
AU  - Kostyu DD
FAU - O'Brien, E
AU  - O'Brien E
FAU - Elias, S
AU  - Elias S
FAU - Simpson, J L
AU  - Simpson JL
FAU - Martin, A O
AU  - Martin AO
LA  - eng
GR  - GM-10356/GM/NIGMS NIH HHS/United States
GR  - N01-HD-02840/HD/NICHD NIH HHS/United States
GR  - R01-CA-19822/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Abortion, Spontaneous
MH  - Birth Intervals
MH  - Contraception
MH  - Female
MH  - *Fertility
MH  - HLA Antigens/immunology
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-DR Antigens
MH  - *Histocompatibility
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Male
MH  - Pregnancy
EDAT- 1985/08/01 00:00
MHDA- 1985/08/01 00:01
CRDT- 1985/08/01 00:00
PHST- 1985/08/01 00:00 [pubmed]
PHST- 1985/08/01 00:01 [medline]
PHST- 1985/08/01 00:00 [entrez]
AID - S0015-0282(16)48742-X [pii]
PST - ppublish
SO  - Fertil Steril. 1985 Aug;44(2):227-32.