PMID- 3865624
OWN - NLM
STAT- MEDLINE
DCOM- 19860109
LR  - 20190912
IS  - 0003-4800 (Print)
IS  - 0003-4800 (Linking)
VI  - 49
IP  - 4
DP  - 1985 Oct
TI  - The affected sib method. IV. Sib trios.
PG  - 303-14
AB  - The classical sib pair method uses the expected and observed HLA (human leukocyte 
      antigen) haplotype sharing distribution in sib pairs, who are affected with an 
      HLA associated disease, to make inferences about the inheritance of the disease. 
      In this paper we present the expected HLA haplotype sharing distributions in 
      affected sib trios, and sib pairs, from families with three or more affected 
      sibs. The underlying model for both distributions, as for the classical sib pair 
      method, is that disease predisposition is determined by a single allele at an 
      HLA-linked locus. The sib trio tests of hypotheses (additive and recessive), and 
      disease parameter estimates (additive, recessive and intermediate), can be 
      compared with those obtained from the classical sib pair analysis. In addition, 
      the sib trio data allow parameter estimation for a general disease model to be 
      made, if the data fall within the bounds of the expectation. This study forms the 
      basis of later investigations which show that haplotype sharing of affected sib 
      trios for two susceptibility alleles (negative complementation) model, which 
      appears appropriate for insulin dependent diabetes mellitus (IDDM), moves outside 
      the bound of the single susceptibility expectations outlined here, whereas 
      haplotype sharing values for sib pairs are bound by the single susceptibility 
      allele expectations. Available Caucasian IDDM data have been analysed. The 
      results support genetic heterogeneity of IDDM.
FAU - Payami, H
AU  - Payami H
FAU - Thomson, G
AU  - Thomson G
FAU - Motro, U
AU  - Motro U
FAU - Louis, E J
AU  - Louis EJ
FAU - Hudes, E
AU  - Hudes E
LA  - eng
GR  - HD12731/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Diabetes Mellitus, Type 1/genetics
MH  - Disease Susceptibility
MH  - Family Characteristics
MH  - Genes, Recessive
MH  - Genetic Markers
MH  - *Genetic Variation
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - *Models, Genetic
MH  - Statistics as Topic
EDAT- 1985/10/01 00:00
MHDA- 1985/10/01 00:01
CRDT- 1985/10/01 00:00
PHST- 1985/10/01 00:00 [pubmed]
PHST- 1985/10/01 00:01 [medline]
PHST- 1985/10/01 00:00 [entrez]
AID - 10.1111/j.1469-1809.1985.tb01706.x [doi]
PST - ppublish
SO  - Ann Hum Genet. 1985 Oct;49(4):303-14. doi: 10.1111/j.1469-1809.1985.tb01706.x.