PMID- 3871800
OWN - NLM
STAT- MEDLINE
DCOM- 19850326
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 12
IP  - 2 Pt 1
DP  - 1985 Feb
TI  - Systemic lupus erythematosus in patients with chronic cutaneous (discoid) lupus 
      erythematosus. Clinical and laboratory findings in seventeen patients.
PG  - 278-88
AB  - The presence of the discoid lupus erythematosus (DLE) skin lesion in a patient 
      with systemic lupus erythematosus (SLE) has been suggested to be a marker of less 
      frequent and less severe renal disease. The clinical and laboratory features of 
      seventeen patients who were seen in a dermatology practice and who had DLE as a 
      manifestation of SLE (DLE-SLE) are reported. DLE preceded the diagnosis of SLE in 
      eight patients. In six patients, the onset was concurrent, whereas in three the 
      SLE was present prior to the discoid skin lesions. Five of the patients had 
      lesions of subacute cutaneous lupus erythematosus (SCLE), and Raynaud's 
      phenomenon occurred in eight patients. Clinical evidence of a renal abnormality 
      was present in six patients (hematuria in three, proteinuria in five, and 
      abnormal renal function in two). Antibodies to nuclear and/or cytoplasmic 
      components were abnormal in all patients. Antibody subsets did not correlate well 
      with clinical findings; only half of those with Raynaud's phenomenon demonstrated 
      a positive ribonucleoprotein; only one patient with SCLE demonstrated anti-Ro 
      (SSA) antibody, but four of the six patients with a renal abnormality had an 
      elevated anti-native deoxyribonucleic acid antibody titer. The cutaneous lesions 
      were eventually widespread in all patients, although two had initial disease that 
      was localized to the head and neck. Although renal disease occurs in this group, 
      it is less common and usually milder than in previous groups of unselected SLE 
      patients.
FAU - Callen, J P
AU  - Callen JP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/*analysis
MH  - Female
MH  - Hematuria/etiology
MH  - Humans
MH  - Lupus Erythematosus, Discoid/diagnosis/*etiology/pathology
MH  - Lupus Erythematosus, Systemic/*complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proteinuria/etiology
MH  - Raynaud Disease/etiology
MH  - Skin/pathology
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - S0190-9622(85)80036-0 [pii]
AID - 10.1016/s0190-9622(85)80036-0 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):278-88. doi: 
      10.1016/s0190-9622(85)80036-0.