PMID- 3872797
OWN - NLM
STAT- MEDLINE
DCOM- 19850612
LR  - 20190813
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 143
IP  - 3
DP  - 1985 Jan
TI  - Hypertension in a neonate with 11 beta-hydroxylase deficiency.
PG  - 231-3
AB  - A female newborn infant with ambiguous genitalia was found to have hypertension 
      (121/82 mm Hg) immediately after birth. The plasma testosterone (T) (0.73 
      nmol/l), delta 4-androstenedione (delta 4-A) (5.9 nmol/l), dehydroepiandrosterone 
      (DHEA) (8.9 nmol/l), as well as 17 OH-hydroxyprogesterone (17 OHP) (152 nmol/l) 
      were elevated. The diagnosis of 11 beta-hydroxylase deficiency was finally 
      established on the basis of elevated plasma eleven-deoxycortisol (compound S) 
      (greater than 0.6 mumol/l) and confirmed by the normalisation of the blood 
      pressure during hydrocortisone therapy. Our case is probably the youngest patient 
      with 11 beta-hydroxylase deficiency in whom the hypertension was found at birth.
FAU - Mimouni, M
AU  - Mimouni M
FAU - Kaufman, H
AU  - Kaufman H
FAU - Roitman, A
AU  - Roitman A
FAU - Morag, C
AU  - Morag C
FAU - Sadan, N
AU  - Sadan N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - EC 1.14.- (Steroid Hydroxylases)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - *Adrenal Hyperplasia, Congenital/drug therapy/*etiology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/therapeutic use
MH  - Hypertension/drug therapy/*etiology
MH  - Infant, Newborn
MH  - Steroid Hydroxylases/*deficiency
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1007/BF00442149 [doi]
PST - ppublish
SO  - Eur J Pediatr. 1985 Jan;143(3):231-3. doi: 10.1007/BF00442149.