PMID- 3874217
OWN - NLM
STAT- MEDLINE
DCOM- 19850812
LR  - 20211203
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 12
IP  - 6
DP  - 1985 Jun
TI  - Human leukocyte antigen associations in basal cell carcinoma.
PG  - 997-1000
AB  - Basal cell carcinoma is the most common form of skin cancer and is one in which 
      both host and environmental factors are thought to play a role in its 
      pathogenesis. For an investigation of the role of human leukocyte antigen 
      (HLA)-associated variations in genetic susceptibility, thirty-one patients with 
      multiple basal cell carcinomas were typed for HLA-A, B, C, and DR antigens. 
      Patients were compared with both local and appropriate ethnic group controls. No 
      statistically significant association with HLA-A, B, or C antigens was noted in 
      any group. However, a significant increase in HLA-DR1 was noted in non-Irish, 
      non-Ashkenazi patients. A tendency toward a decrease in HLA-DR3 was also noted 
      among patients of Irish or Ashkenazi Jewish descent. The role of HLA-associated 
      genetic factors in this form of skin cancer needs further investigation.
FAU - Myskowski, P L
AU  - Myskowski PL
FAU - Pollack, M S
AU  - Pollack MS
FAU - Schorr, E
AU  - Schorr E
FAU - Dupont, B
AU  - Dupont B
FAU - Safai, B
AU  - Safai B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR1 Antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Carcinoma, Basal Cell/*genetics
MH  - Ethnicity
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-C Antigens
MH  - HLA-DR Antigens
MH  - HLA-DR1 Antigen
MH  - HLA-DR3 Antigen
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Ireland/ethnology
MH  - Jews
MH  - New York City
MH  - Skin Neoplasms/*genetics
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
AID - S0190-9622(85)70127-2 [pii]
AID - 10.1016/s0190-9622(85)70127-2 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1985 Jun;12(6):997-1000. doi: 10.1016/s0190-9622(85)70127-2.