PMID- 3876142
OWN - NLM
STAT- MEDLINE
DCOM- 19851106
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 15
IP  - 2
DP  - 1985 Aug
TI  - Perfusion of vasopressin within the ventral septum of the rabbit suppresses 
      endotoxin fever.
PG  - 209-13
AB  - The antipyretic action of arginine vasopressin (AVP), administered into a lateral 
      cerebral ventricle or directly into the brain tissue via push-pull perfusion, was 
      investigated in conscious New Zealand White rabbits. Administration of AVP into a 
      lateral cerebral ventricle (ICV) was ineffective in reducing an endotoxin-induced 
      fever and did not alter body temperature in the afebrile rabbit. Control 
      push-pull perfusions with the carrier vehicle were without effect on endotoxin 
      fevers or normal body temperature. Perfusion of the vehicle containing AVP 
      provided significant antipyretic activity against both intravenous (IV) and ICV 
      endotoxin without affecting normal body temperature. Both the maximum fever 
      height and the fever index were significantly reduced during AVP perfusion. 
      Tissue sites in which AVP was found to be antipyretic were located in the 
      rostroventral parts of the septal region, at sites similar to those where 
      perfusion of the peptide caused antipyresis in the sheep and rat. These results 
      support the hypothesis that AVP, or a closely related molecule, may modulate 
      fever within the central nervous system.
FAU - Naylor, A M
AU  - Naylor AM
FAU - Ruwe, W D
AU  - Ruwe WD
FAU - Kohut, A F
AU  - Kohut AF
FAU - Veale, W L
AU  - Veale WL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Bacterial Toxins)
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Animals
MH  - *Anti-Inflammatory Agents, Non-Steroidal
MH  - Arginine Vasopressin/*therapeutic use
MH  - Bacterial Toxins/*antagonists & inhibitors
MH  - Brain Mapping
MH  - Fever/chemically induced/*drug therapy
MH  - Injections
MH  - Injections, Intraventricular
MH  - Male
MH  - Rabbits
MH  - Salmonella
MH  - Septum Pellucidum/*drug effects
EDAT- 1985/08/01 00:00
MHDA- 1985/08/01 00:01
CRDT- 1985/08/01 00:00
PHST- 1985/08/01 00:00 [pubmed]
PHST- 1985/08/01 00:01 [medline]
PHST- 1985/08/01 00:00 [entrez]
AID - 0361-9230(85)90138-8 [pii]
AID - 10.1016/0361-9230(85)90138-8 [doi]
PST - ppublish
SO  - Brain Res Bull. 1985 Aug;15(2):209-13. doi: 10.1016/0361-9230(85)90138-8.