PMID- 3876966
OWN - NLM
STAT- MEDLINE
DCOM- 19851213
LR  - 20101118
IS  - 0741-0395 (Print)
IS  - 0741-0395 (Linking)
VI  - 2
IP  - 1
DP  - 1985
TI  - A linkage analysis of the Gm locus and multiple sclerosis.
PG  - 29-34
AB  - We conducted linkage analyses of immunoglobulin G heavy chain marker (Gm) 
      phenotypes and multiple sclerosis (MS) in 30 families, each having at least two 
      first-degree relatives with definite/probable MS. These families yielded positive 
      evidence for linkage to human leukocyte antigen (HLA) loci in previous analyses. 
      In the present analysis, however, the results for Gm were negative. Most lod 
      scores were negative, particularly at the smaller recombination values (theta). 
      We explored the possibility of heterogeneity by subgrouping our data on the basis 
      of specific HLA types (A3, B7) and Gm types (Gm1, Gm1,2) within the pedigrees. 
      The results were again negative with no substantial differences in estimates of 
      theta between subgroups.
FAU - Haile, R W
AU  - Haile RW
FAU - Goldstein, A
AU  - Goldstein A
FAU - Field, L
AU  - Field L
FAU - Marazita, M L
AU  - Marazita ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Epidemiol
JT  - Genetic epidemiology
JID - 8411723
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (Immunoglobulin Allotypes)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - HLA Antigens/genetics
MH  - HLA-A3 Antigen
MH  - HLA-B7 Antigen
MH  - Humans
MH  - Immunoglobulin Allotypes/*genetics
MH  - Immunoglobulin G/*genetics
MH  - Multiple Sclerosis/*genetics/immunology
MH  - Pedigree
MH  - Phenotype
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1002/gepi.1370020104 [doi]
PST - ppublish
SO  - Genet Epidemiol. 1985;2(1):29-34. doi: 10.1002/gepi.1370020104.