PMID- 3877312
OWN - NLM
STAT- MEDLINE
DCOM- 19851218
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 34
IP  - 6
DP  - 1985 Jun
TI  - The substrates for self-stimulation of the lateral hypothalamus and medial 
      prefrontal cortex: a comparison of strength-duration characteristics.
PG  - 943-9
AB  - The directly activated substrates for self-stimulation of the lateral 
      hypothalamus (LH) and medial prefrontal cortex (MPFC) were described by comparing 
      their strength-duration characteristics. The current required to maintain a 
      half-maximal rate of lever pressing was traded off against the pulse duration 
      while all other stimulation parameters were kept constant. In this manner, 
      cathodal strength-duration curves were obtained at four LH and eight MPFC sites; 
      anodal curves were obtained at two of the LH and six of the MPFC sites. In 
      general, the cathodal LH curves had lower rheobases than the cathodal MPFC curves 
      and continued to descend after the MPFC curves had levelled off. At short pulse 
      durations, the anodal curves lay above the cathodal curves, a finding more 
      pronounced in the LH data. The two sets of curves converged at the longer pulse 
      durations. The differences in the strength-duration curves are consistent with 
      the notion that different directly stimulated neurons are responsible for the 
      rewarding effects of LH and MPFC stimulation. Anatomical and physiological 
      properties that could account for these differences are discussed.
FAU - Schenk, S
AU  - Schenk S
FAU - Shizgal, P
AU  - Shizgal P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Electric Stimulation
MH  - Frontal Lobe/*physiology
MH  - Hypothalamic Area, Lateral/*physiology
MH  - Male
MH  - Medial Forebrain Bundle/*physiology
MH  - Neural Pathways/*physiology
MH  - Rats
MH  - Refractory Period, Electrophysiological
MH  - Reward
MH  - Self Stimulation/*physiology
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
AID - 0031-9384(85)90017-4 [pii]
AID - 10.1016/0031-9384(85)90017-4 [doi]
PST - ppublish
SO  - Physiol Behav. 1985 Jun;34(6):943-9. doi: 10.1016/0031-9384(85)90017-4.