PMID- 3878241
OWN - NLM
STAT- MEDLINE
DCOM- 19860130
LR  - 20181113
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 61
IP  - 3
DP  - 1985 Sep
TI  - Epidermal T lymphocytes and dendritic cells in chronic plaque psoriasis: the 
      effects of PUVA treatment.
PG  - 526-34
AB  - The numbers and HLA-DR expression of T cell subsets and dendritic cells in 
      chronic psoriatic plaques were compared to previously reported findings in 
      spontaneously resolving guttate lesions, and the effects of PUVA treatment on 
      these cell populations studied. The chronic lesions showed a similar T helper/T 
      suppressor (TH/TS) ratio (0.66 +/- 0.10) to resolving guttate lesions. However, 
      in contrast to the resolving lesions which do not contain activated epidermal TH 
      cells, a substantial proportion of the TH cells in the persistent plaques were 
      DR+. Moreover, these persistent lesions contained markedly increased numbers of 
      DR+ dendritic cells, approximately 20% of which were T6 negative. PUVA-induced 
      resolution of chronic lesions was associated with depletion of epidermal TH and 
      TS cells, and a subsequent reduction in DR+ dendritic cells. In each patient the 
      rate of disappearance of both cell types correlated with the rate of resolution. 
      Furthermore, the epidermal T cell depletion preceded the onset of clinical 
      improvement. In contrast, significant reduction of the dendritic cells was 
      generally not observed until the lesions were largely resolved. Dendritic cells 
      decreased faster in uninvolved than in lesional skin and to a subnormal level. 
      Dermal T cells also decreased during PUVA therapy but this did not show any 
      obvious correlation with resolution of the lesions. Blood T cell levels were not 
      significantly affected by the treatment. These findings support the concept that 
      the initiation and maintenance of the psoriatic process requires activation of TH 
      cells in the epidermis via interaction with antigen presenting cells. Furthermore 
      PUVA treatment may clear psoriasis by interfering with such a mechanism through 
      its effects on T lymphocytes.
FAU - Baker, B S
AU  - Baker BS
FAU - Swain, A F
AU  - Swain AF
FAU - Griffiths, C E
AU  - Griffiths CE
FAU - Leonard, J N
AU  - Leonard JN
FAU - Fry, L
AU  - Fry L
FAU - Valdimarsson, H
AU  - Valdimarsson H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Epidermis/immunology/pathology
MH  - Female
MH  - HLA-DR Antigens
MH  - Histocompatibility Antigens Class II/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *PUVA Therapy
MH  - Psoriasis/drug therapy/*immunology
MH  - Skin/*immunology
MH  - T-Lymphocytes/classification/*drug effects/immunology
PMC - PMC1577286
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
PMCR- 1986/09/01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
PHST- 1986/09/01 00:00 [pmc-release]
PST - ppublish
SO  - Clin Exp Immunol. 1985 Sep;61(3):526-34.