PMID- 3884275
OWN - NLM
STAT- MEDLINE
DCOM- 19850523
LR  - 20211203
IS  - 0090-3493 (Print)
IS  - 0090-3493 (Linking)
VI  - 13
IP  - 4
DP  - 1985 Apr
TI  - Acute respiratory failure due to Pneumocystis carinii pneumonia: clinical, 
      radiographic, and pathologic course.
PG  - 237-43
AB  - The clinical, radiographic, and pathologic correlates of acute respiratory 
      failure due to Pneumocystis carinii pneumonia were studied in 12 renal transplant 
      patients treated with cyclosporin (CS) and prednisone. Six patients required only 
      supplemental oxygen, while the other six patients developed the adult respiratory 
      distress syndrome (ARDS) requiring prolonged mechanical ventilation despite 
      similar predisposing factors and prompt initiation of therapy. Ten (83%) patients 
      survived. Increased frequency of human leukocyte antigen (HLA) DR6 was noted in 
      six of the 11 patients tested. The resolution of radiographic infiltrates was 
      significantly slower in ARDS patients; however, there was no apparent difference 
      in the severity of early alveolar damage between the two groups. There was also 
      no association between the development of ARDS due to P. carinii pneumonia and 
      the mean daily dose of CS and prednisone, the presence of cytomegalovirus 
      infection or pneumonia, HLA-DR6 antigen, or initial hypoxemia.
FAU - Suffredini, A F
AU  - Suffredini AF
FAU - Tobin, M J
AU  - Tobin MJ
FAU - Wajszczuk, C P
AU  - Wajszczuk CP
FAU - Slasky, B S
AU  - Slasky BS
FAU - Peel, R L
AU  - Peel RL
FAU - Carpenter, B J
AU  - Carpenter BJ
FAU - Ho, M
AU  - Ho M
FAU - Grenvik, A
AU  - Grenvik A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Oxygen Inhalation Therapy
MH  - *Pneumonia, Pneumocystis/diagnostic imaging/pathology/physiopathology
MH  - Pulmonary Alveoli/microbiology/pathology
MH  - Radiography
MH  - Respiration, Artificial
MH  - Respiratory Distress Syndrome/diagnostic imaging/etiology/pathology
MH  - *Respiratory Insufficiency/diagnostic imaging/pathology/physiopathology
EDAT- 1985/04/01 00:00
MHDA- 1985/04/01 00:01
CRDT- 1985/04/01 00:00
PHST- 1985/04/01 00:00 [pubmed]
PHST- 1985/04/01 00:01 [medline]
PHST- 1985/04/01 00:00 [entrez]
AID - 10.1097/00003246-198504000-00006 [doi]
PST - ppublish
SO  - Crit Care Med. 1985 Apr;13(4):237-43. doi: 10.1097/00003246-198504000-00006.