PMID- 3884573
OWN - NLM
STAT- MEDLINE
DCOM- 19850508
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 58
IP  - 2
DP  - 1985 Feb
TI  - Antigen sensitization and methacholine responses in dogs with hyperreactive 
      airways.
PG  - 485-91
AB  - Antigen sensitization was induced in six Basenji-Greyhound (BG) dogs by weekly 
      aerosol exposure to Ascaris suum. The effects on airway responsiveness to inhaled 
      methacholine were studied before and at least 2 wk following Ascaris 
      sensitization. All dogs developed detectable serum levels of Ascaris-specific 
      immunoglobulin E (IgE), and five out of six dogs developed airway responsiveness 
      to antigen over the 4- to 6-mo period. This was accompanied by a decrease rather 
      than an increase in airway responsiveness to inhaled methacholine. When dogs were 
      challenged with methacholine 30 min after Ascaris antigen aerosol challenge, 
      however, dogs reactive to Ascaris became hyperresponsive to methacholine. The 
      magnitude of the response to antigen correlated (r = 0.85) inversely with the 
      dose of methacholine increasing pulmonary resistance 200%. These data show that 
      in BG dogs airway responsiveness to methacholine is increased by acute antigen 
      exposure but that sensitization of previously unsensitized dogs does not increase 
      nonspecific airway responsiveness.
FAU - Hirshman, C A
AU  - Hirshman CA
FAU - Downes, H
AU  - Downes H
LA  - eng
GR  - HL-25831/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Aerosols)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Methacholine Compounds)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aerosols
MH  - Animals
MH  - Antigens, Helminth/*immunology
MH  - Ascaris/*immunology
MH  - Bronchial Spasm/chemically induced/*immunology
MH  - Dogs
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Immunization
MH  - Immunoglobulin E/immunology
MH  - Lung Compliance
MH  - Methacholine Chloride
MH  - *Methacholine Compounds
MH  - Time Factors
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 10.1152/jappl.1985.58.2.485 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1985 Feb;58(2):485-91. doi: 10.1152/jappl.1985.58.2.485.