PMID- 3886084
OWN - NLM
STAT- MEDLINE
DCOM- 19850617
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 350
IP  - 1-2
DP  - 1985 Feb
TI  - A quantitative, immunochemical demonstration of the postnatal development of 
      neurotensin in the medial preoptic area of the rat.
PG  - 241-50
AB  - The postnatal ontogeny of neurotensin (NT) in the medial preoptic area (MPO) of 
      the rat was quantitatively investigated using immunocytochemical and 
      neurochemical techniques. On postpartum day 0, NT-like immunoreactive neurons 
      could not be identified within the MPO by peroxidase-antiperoxidase 
      histochemistry and, in fact, did not appear until 9 days postpartum. After this 
      age, the number of NT cells in the MPO increased ontogenetically, as did 
      concentrations of NT in MPO extracts measured by radioimmunoassay and 
      enzyme-linked immunosorbent assay. In organotypic MPO explants derived from 
      neonatal rats, NT-like immunoreactivity was detected only after the explants were 
      maintained 14 days in vitro, after which, the number of NT-like immunoreactive 
      somata increased as the time in vitro was extended. These findings indicate that 
      a substantial amount of differentiation occurs postnatally in the MPO both in 
      vivo and in vitro and, more specifically, that the ontogenetic expression of NT 
      may be an intrinsic property of the MPO.
FAU - Wolfson, B
AU  - Wolfson B
FAU - Manning, R W
AU  - Manning RW
FAU - Davis, L G
AU  - Davis LG
FAU - Baldino, F Jr
AU  - Baldino F Jr
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 39379-15-2 (Neurotensin)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Neurotensin/*analysis/metabolism
MH  - Preoptic Area/*analysis/growth & development/metabolism
MH  - Radioimmunoassay
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1985/02/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 10.1016/0165-3806(85)90268-8 [doi]
PST - ppublish
SO  - Brain Res. 1985 Feb;350(1-2):241-50. doi: 10.1016/0165-3806(85)90268-8.